{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:57:03Z","timestamp":1792033023637,"version":"4.4.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Rosacea is a chronic skin condition that affects self-esteem and quality of life. However, data on depression and anxiety in patients with rosacea are scarce. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate the relationship between rosacea and new-onset depression and anxiety disorders. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data on all Danish citizens aged \u226518 years between January 1, 1997, and December 31, 2011, were linked at individual level in nationwide registers. Incidence rates per 1,000 person-years were calculated, and crude and adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were estimated by Poisson regression models. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The study comprised a total of 4,632,341 individuals, including 30,725 and 24,712 patients with mild and moderate-to-severe rosacea, respectively. Mild and moderate-to-severe rosacea increased the risk of both depression [IRR 1.89 (95% CI 1.82-1.96) and IRR 2.04 (95% CI 1.96-2.12)] and anxiety disorders [IRR 1.80 (95% CI 1.75-1.86) and IRR 1.98 (95% CI 1.91-2.05)]. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea.<\/jats:p>","DOI":"10.1159\/000444082","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T17:01:15Z","timestamp":1457456475000},"page":"208-213","source":"Crossref","is-referenced-by-count":94,"title":["Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study"],"prefix":"10.1159","volume":"232","author":[{"given":"Alexander","family":"Egeberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Riis","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar Hilmar","family":"Gislason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Pontoppidan","family":"Thyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3410\/f.718430973.793495881"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12385"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.141"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.036"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06895.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/76396"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.09.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05306.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811405098"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515\/9783110804904.263"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.350"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2183"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413483930"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.255"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2013.841968"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181960e7f"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.019"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.413"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmp071"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:44:02Z","timestamp":1745415842000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000444082","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5129428","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.726205677.793552699","asserted-by":"object"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}