{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:10:58Z","timestamp":1785363058614,"version":"3.55.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Gait disorders are common in early dementia, with particularly pronounced dual-task deficits, contributing to the increased fall risk and mobility decline associated with cognitive impairment. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; This study examines the effects of a combined cognitive stimulation and physical exercise programme (MINDVital) on gait performance under single- and dual-task conditions in older adults with mild dementia. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty-nine patients with early dementia participated in a multi-disciplinary rehabilitation programme comprising both physical exercise and cognitive stimulation. The programme was conducted in 8-week cycles with participants attending once weekly, and all participants completed 2 successive cycles. Cognitive, functional performance and behavioural symptoms were assessed at baseline and at the end of each 8-week cycle. Gait speed was examined under both single- (Timed Up and Go and 6-metre walk tests) and dual-task (animal category and serial counting) conditions. A random effects model was performed for the independent effect of MINDVital on the primary outcome variable of gait speed under dual-task conditions. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean age of patients enroled in the rehabilitation programme was 79 \u00b1 6.2 years; 25 (64.1%) had a diagnosis of Alzheimer's dementia, and 26 (66.7%) were receiving a cognitive enhancer therapy. There was a significant improvement in cognitive performance [random effects coefficient (standard error) = 0.90 (0.31), p = 0.003] and gait speed under both dual-task situations [animal category: random effects coefficient = 0.04 (0.02), p = 0.039; serial counting: random effects coefficient = 0.05 (0.02), p = 0.013], with reduced dual-task cost for gait speed [serial counting: random effects coefficient = -4.05 (2.35), p = 0.086] following successive MINDVital cycles. No significant improvement in single-task gait speed was observed. Improved cognitive performance over time was a significant determinant of changes in dual-task gait speed [random effects coefficients = 0.01 (0.005), p = 0.048, and 0.02 (0.005), p = 0.003 for category fluency and counting backwards, respectively]. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A combined physical and cognitive rehabilitation programme leads to significant improvements in dual-task walking in early dementia, which may be contributed by improvement in cognitive performance, as single-task gait performance remained stable.<\/jats:p>","DOI":"10.1159\/000444084","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:01:49Z","timestamp":1456437709000},"page":"604-610","source":"Crossref","is-referenced-by-count":30,"title":["A Combined Cognitive Stimulation and Physical Exercise Programme (MINDVital) in Early Dementia: Differential Effects on Single- and Dual-Task Gait Performance"],"prefix":"10.1159","volume":"62","author":[{"given":"Laura","family":"Tay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Shiong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorhazlina","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-5901","authenticated-orcid":false,"given":"Mei Sian","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.08.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000371577"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-014-0228-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq127"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11556-006-0007-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.8.844"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1037\/\/0882-7974.15.3.417"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3256"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-14-134"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2007.12.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(200003)15:3<234::AID-GPS99>3.0.CO;2-G"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01802.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2010.06.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100114"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.250"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-014-0845-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03206.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2013.12.026"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00701.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000091"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e39696"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:44:04Z","timestamp":1745430244000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,10,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000444084","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}