{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:27:40Z","timestamp":1791491260112,"version":"4.3.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Orthostatic tremor (OT) is characterized by high-frequency leg tremor when standing still, resulting in a sense of imbalance, with limited treatment options. Ventral intermediate (Vim) nucleus thalamic deep brain stimulation (DBS) has been reported as beneficial in a few cases. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To report clinical outcomes, lead locations, and stimulation parameters in 2 patients with severe medication-refractory OT treated with Vim DBS. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The patients underwent surface electromyography (EMG) to confirm the OT diagnosis. Outcomes were measured as change in tolerated standing time at the last follow-up. Lead locations were quantified using postoperative MRI. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;Vim DBS was well tolerated and resulted in improvement in standing time (patient 1: 50 s at baseline to 15 min 16 months after surgery; patient 2: 34 s at baseline to 4.2 min 7 months after surgery). Postoperative surface EMG for patient 1 demonstrated a delayed onset of tremor, lower-amplitude tremor, and periods of quiescence, but an unchanged tremor frequency. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; These cases provide further support for Vim DBS to improve standing time in severe medication-refractory OT. The location of the effective thalamic target for OT does not differ from the effective target for essential tremor.<\/jats:p>","DOI":"10.1159\/000444127","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T22:01:25Z","timestamp":1458684085000},"page":"69-74","source":"Crossref","is-referenced-by-count":18,"title":["Bilateral Ventral Intermediate Nucleus Thalamic Deep Brain Stimulation in Orthostatic Tremor"],"prefix":"10.1159","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-7887","authenticated-orcid":false,"given":"Robert R.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Volz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suketu M.","family":"Khandhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill L.","family":"Ostrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20132"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.03.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0980-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.086132"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22271"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7916\/D8TQ608K"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23333"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25616"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7916\/D8NZ86C1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.06.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0370"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:44:42Z","timestamp":1745430282000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,5,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000444127","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}