{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:05:02Z","timestamp":1791731102171,"version":"4.3.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Extremely-low-birth-weight (ELBW; \u22641,000 g) infants are at high risk for neurodevelopmental impairments. Conventional brain MRI at term-equivalent age is increasingly used for prediction of outcomes. However, optimal prediction models remain to be determined, especially for cognitive outcomes. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim was to evaluate the accuracy of a data-driven MRI scoring system to predict neurodevelopmental impairments. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 122 ELBW infants had a brain MRI performed at term-equivalent age. Conventional MRI findings were scored with a standardized algorithm and tested using a multivariable regression model to predict neurodevelopmental impairment, defined as one or more of the following at 18-24 months' corrected age: cerebral palsy, bilateral blindness, bilateral deafness requiring amplification, and\/or cognitive\/language delay. Results were compared with a commonly cited scoring system. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In multivariable analyses, only moderate-to-severe gyral maturational delay was a significant predictor of overall neurodevelopmental impairment (OR: 12.6, 95% CI: 2.6, 62.0; p &lt; 0.001). Moderate-to-severe gyral maturational delay also predicted cognitive delay, cognitive delay\/death, and neurodevelopmental impairment\/death. Diffuse cystic abnormality was a significant predictor of cerebral palsy (OR: 33.6, 95% CI: 4.9, 229.7; p &lt; 0.001). These predictors exhibited high specificity (range: 94-99%) but low sensitivity (30-67%) for the above outcomes. White or gray matter scores, determined using a commonly cited scoring system, did not show significant association with neurodevelopmental impairment. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In our cohort, conventional MRI at term-equivalent age exhibited high specificity in predicting neurodevelopmental outcomes. However, sensitivity was suboptimal, suggesting additional clinical factors and biomarkers are needed to enable accurate prognostication.<\/jats:p>","DOI":"10.1159\/000444179","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:40:15Z","timestamp":1459989615000},"page":"47-54","source":"Crossref","is-referenced-by-count":34,"title":["Early Conventional MRI for Prediction of Neurodevelopmental Impairment in Extremely-Low-Birth-Weight Infants"],"prefix":"10.1159","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-1619","authenticated-orcid":false,"given":"Laurel A.","family":"Slaughter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Bonfante-Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Hintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Dvorchik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1150"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000260136"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1416"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0772-L"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(97)90556-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1866"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb01337.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053792"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0898"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051879"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.09.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072974"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.162.1.3786767"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00294.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010109"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198811000-00002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.047"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318233b215"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.053"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2025"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.026"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3521"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:11Z","timestamp":1745430311000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000444179","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5129458","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}