{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:29:47Z","timestamp":1748431787325,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Objective:<\/i><\/b> The suppressor gene<i> CHEK2<\/i> encodes a cell cycle checkpoint kinase, involved in cell cycle regulation, apoptosis and response to DNA damage. The aim of this study was to analyze the differences between <i>CHEK2 <\/i>mutation carriers (<i>CHEK2<\/i>*1100delC\/I157T) and noncarriers with respect to clinicopathological factors. <b><i>Methods:<\/i><\/b> We reviewed the medical records of 100 early breast cancer patients (46 mutation carriers and 54 noncarriers) who were treated with chemotherapy, hormonotherapy or trastuzumab. <b><i>Results:<\/i><\/b><i>CHEK2<\/i> mutation carriers were older (>65 years) than noncarriers (17 vs. 7%; p = 0.215). Twenty-five (54%) of them had a history of cancer in the family. Gastric cancer in the family history was detected in 11% of mutation carriers and in 2% of noncarriers (p = 0.092). There was a trend for more frequent lymph node metastases in patients without the mutation in comparison to mutation carriers (46 vs. 28%; p = 0.098). Luminal B type breast cancer was detected more often in carriers (39 vs. 20%; p = 0.048). Breast-conserving treatment was also conducted more often in mutation carriers (57 vs. 31%; p = 0.015). Histologic grades G1\/G2 were detected more frequently in mutation carriers (82 vs. 70%; p = 0.212). <b><i>Conclusion:<\/i><\/b> Mutation carriers were characterized by older age, a history of gastric cancer in the family, locally advanced disease, lower histologic grade and luminal B type breast cancer.<\/jats:p>","DOI":"10.1159\/000444326","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T23:07:21Z","timestamp":1458601641000},"page":"193-198","source":"Crossref","is-referenced-by-count":9,"title":["A Comparison between <b><i>CHEK2<\/i><\/b>*1100delC\/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis"],"prefix":"10.1159","volume":"90","author":[{"given":"Joanna","family":"Huszno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Budryk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Ko\u0142osza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"T\u0119cza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Pamu\u0142a Pi\u0142at","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Nowara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Grzybowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/294575"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.4.1355"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.033"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds101"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209877"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/bcr933"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20638"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3062"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.01.009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.5160"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.5922"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.7336"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086\/421251"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2013.1970"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20299"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086\/426403"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000010697.49896.03"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.306"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604228"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00694.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1635-7"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:46:43Z","timestamp":1745430403000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000444326","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2016]]}}}