{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:46:08Z","timestamp":1774914368379,"version":"3.50.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic entity of unknown origin characterized by loss of inter-lobular bile ducts that was first described two decades ago. Although the diagnostic criteria have been described in detail, IAD continues to be a rare diagnosis. Our thorough literature search revealed less than a hundred cases of IAD reported. Here we present a 34-year-old female with no significant past history who was evaluated for persistent elevation of serum alkaline phosphate levels. Serology was negative for all viral hepatitides, and a chronic liver disease workup was unremarkable. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography did not reveal any abnormalities in the biliary tree. Finally, a liver biopsy demonstrated ductopenia involving greater than 50% of the portal triads, making a diagnosis of IAD. Since the disease can progress rapidly, close follow-up is warranted, so liver transplantation can be pursued if deemed necessary.<\/jats:p>","DOI":"10.1159\/000444443","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T21:01:22Z","timestamp":1462222882000},"page":"99-102","source":"Crossref","is-referenced-by-count":8,"title":["Idiopathic Adulthood Ductopenia: 'It Is Out There'"],"prefix":"10.1159","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-212X","authenticated-orcid":false,"given":"Mohammad","family":"Bilal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Babich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(88)80482-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)00791-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4065\/73.3.285"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200003000-00018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703203361204"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou048"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444443","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:48:00Z","timestamp":1745430480000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,4,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000444443","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}