{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:35Z","timestamp":1761823775065,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We assessed the clinical applicability of the F-NLR score, which is based on fibrinogen (F) and the neutrophil-lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) to predict the therapeutic effects of chemotherapy or chemoradiotherapy on advanced gastric cancer and the prognoses of patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Sixty-eight patients with advanced gastric cancer treated with first-line chemotherapy or chemoradiotherapy were classified into two groups based on tumor response. Furthermore, we categorized patients according to cutoff F-NLR scores of 2 [hyperfibrinogenemia (&gt;400 mg\/dl) and high NLR (&gt;3.0)], 1 [one of these hematological abnormalities], and 0 [neither hyperfibrinogenemia nor high NLR]. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 27 patients had progressive disease (PD) and 41 did not. The F-NLR scores were significantly higher in the PD than in the non-PD group (p = 0.003). Survival was significantly shorter for patients with high F-NLR scores and GPS (p = 0.0071 and p = 0.0065, respectively). Multivariate analysis selected the F-NLR score as an independent prognostic factor (p = 0.017). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A novel grading system based on F-NLR scores, as well as the GPS, appears to have value as a clinical predictor of the therapeutic response of advanced gastric cancer to chemotherapy or chemoradiotherapy and the prognoses of patients.<\/jats:p>","DOI":"10.1159\/000444494","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T22:01:55Z","timestamp":1458252115000},"page":"186-192","source":"Crossref","is-referenced-by-count":23,"title":["A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer"],"prefix":"10.1159","volume":"90","author":[{"given":"Takaaki","family":"Arigami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Uenosono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiya","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Yanagita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Uchikado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Nakajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kurahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Maemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Natsugoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12814"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-012-0163-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0042-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2177-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.05.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4840"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.7136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307191"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04736.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5754\/hge11133"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01780.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-013-0330-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2014.07.009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.02.015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001702"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.08.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602998"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a3e738"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.262"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1411-1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3962-5"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a3e738"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.015"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03147.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.09.015"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:48:28Z","timestamp":1745430508000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-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