{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:35:06Z","timestamp":1770752106922,"version":"3.50.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Systemic mastocytosis (SM) patients are at a high risk for anaphylaxis, with Hymenoptera as the main culprit. A screening instrument to identify which patients are sensitized to Hymenoptera before they experience anaphylaxis would therefore be of great value. The basophil activation test (BAT) is proposed as a possible tool for diagnosing Hymenoptera venom-related allergy (HVA), especially in patients in whom conventional allergy tests yield contradictory results. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We included outpatients with SM, according to WHO criteria, from September 2011 to January 2012. Next, to obtain various clinical data including intradermal test results, specific immunoglobulin E (sIgE) measurements and BAT were performed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We included 29 patients, 9 of whom had a history of HVA and 4 of whom had experienced anaphylaxis due to other triggers. Sixteen patients had no history of anaphylaxis. sIgE was detected in 6 patients with HVA and in 2 patients with anaphylaxis due to other triggers. The BAT was positive in only 1 patient, in whom the skin test and sIgE were also positive. Compared to patients with skin lesions, those without skin lesions had significantly more anaphylaxis and sIgE to Hymenoptera. During a 3-year follow-up, no one experienced new anaphylactic episodes. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The BAT is not a reliable tool for randomly screening SM patients for HVA.<\/jats:p>","DOI":"10.1159\/000444996","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T11:33:39Z","timestamp":1460115219000},"page":"125-129","source":"Crossref","is-referenced-by-count":10,"title":["The Basophil Activation Test Is Not a Useful Screening Tool for Hymenoptera Venom-Related Anaphylaxis in Patients with Systemic Mastocytosis"],"prefix":"10.1159","volume":"169","author":[{"given":"Mark J.A.","family":"Rietveld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco W.J.","family":"Schreurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-8742","authenticated-orcid":false,"given":"Roy","family":"Gerth van Wijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.A.","family":"van Daele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud A.W.","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:34:2:97"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12225"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01569.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000083954"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000329218"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/all.12698"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000348500"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000355199"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/all.12436"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02050.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01305.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00400.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21148"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02809.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02849.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20577"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832dd1f5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000115885"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444996","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:52:33Z","timestamp":1745430753000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,4,1]]},"published-print":{"date-parts":[[2016,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000444996","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}