{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:53:11Z","timestamp":1768884791167,"version":"3.49.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Objectives: Galectin-3 (Gal-3) is involved in cardiac inflammation and fibrosis, and is in use as a biomarker that indicates increased risk in heart failure. This study examined the relationship between Gal-3 levels and acute and old myocardial infarction (MI) in patients assessed by cardiac magnetic resonance (CMR) imaging. Methods: Group 1 consisted of 38 patients with ST-elevation MI and single-vessel disease treated with primary percutaneous coronary intervention (PCI). Group 2 consisted of 52 patients with prior complicated MI. Twenty-two controls were included. CMR was performed in group 1 at 2 days, 1 week, 2 months and 1 year following PCI and in group 2 at &gt;4 years after MI. Results: Median Gal-3 was elevated in patients compared with controls, group 1: 11.93 ng\/ml (IQR 6.34-17.52, p = 0.03), group 2: 12.96 (IQR 6.33-19.29, p = 0.03) and controls: 10.16 (IQR 5.59-14.73). Gal-3 levels did not change during acute MI, and there was no relationship between Gal-3 and infarct size, troponin-T, high-sensitivity C-reactive protein, left-ventricular (LV) volumes or LV ejection fraction (LVEF) in group 1. In group 2, Gal-3 correlated modestly with MI size (r = 0.28, p &lt; 0.05), LV end-diastolic volume index (r = 0.40, p &lt; 0.01), LV end-systolic volume index (r = 0.43, p &lt; 0.01) and LVEF (r = -0.39, p &lt; 0.01). Conclusion: There was no relationship between Gal-3 levels and acute ischemic myocardial injury. A significant, modest relationship between Gal-3 levels, MI size and LV remodeling was only found in patients with old MI.<\/jats:p>","DOI":"10.1159\/000445103","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T16:23:35Z","timestamp":1461860615000},"page":"398-405","source":"Crossref","is-referenced-by-count":21,"title":["Circulating Galectin-3 Levels Are Increased in Patients with Ischemic Heart Disease, but Are Not Influenced by Acute Myocardial Infarction"],"prefix":"10.1159","volume":"134","author":[{"given":"Erlend G.","family":"Singsaas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cord A.","family":"Manhenke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-4592","authenticated-orcid":false,"given":"Stein","family":"Orn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp097"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.10.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.053"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02476.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq091"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.538080"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.081"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs077"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs205"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8776"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304964"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.11.089"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09895-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00747.2008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5551\/jat.12856"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.087"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000146"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.10.034"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3315"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1309\/LM3JZKBDA7D4QFOC"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-91"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.129"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.246"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.059"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.122622"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036014.90197.FA"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.1.44"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.07.006"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht482"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crd\/article-pdf\/134\/4\/398\/3895300\/000445103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/134\/4\/398\/3895300\/000445103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:51Z","timestamp":1745430831000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,12]]},"published-print":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000445103","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}