{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:56:02Z","timestamp":1760122562814,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To assess the efficacy and safety of a new medical device (MD; a capsule whose main component is a cross-linked protein) in the prevention of uncomplicated cystitis recurrences. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Adult women with acute cystitis symptoms and a ciprofloxacin-susceptible isolate in urine culture were included in a randomized, double-blind clinical trial. Patients were treated with ciprofloxacin 500 mg\/day and 1 capsule\/day or matched placebo for 5 days, 1 capsule\/day or placebo for 15 additional days, and 2 additional cycles of 1 capsule\/day or placebo for 15 days on months 1 and 2 after initial treatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; No recurrence was observed after the first month of follow-up in the MD-treated group. In addition, symptomatic recurrence was reduced by 19.4% compared with placebo after 6 months. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The new MD can help prevent the recurrence of uncomplicated cystitis as well as help to reduce antibiotic use in management of urinary tract infection in women.<\/jats:p>","DOI":"10.1159\/000445326","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T11:33:30Z","timestamp":1460115210000},"page":"347-351","source":"Crossref","is-referenced-by-count":11,"title":["A New Approach to the Treatment of Uncomplicated Cystitis: Results of a Randomized Placebo-Controlled Clinical Trial"],"prefix":"10.1159","volume":"97","author":[{"given":"Nicola","family":"Salvatorelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Garc\u00eda-Larrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Allegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mda.2003.7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.04.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1157\/13091444"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01056-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010170"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01055-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2011.05.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60401-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283398dc1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.199"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-015-0095-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2014.10.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001209.pub2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.0117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2001.0371"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000585"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:56:26Z","timestamp":1745430986000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,10,11]]},"published-print":{"date-parts":[[2016,10,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000445326","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2016]]}}}