{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:24:46Z","timestamp":1790389486749,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Objective:<\/i><\/b> To explore a possible role for activity-regulated cytoskeleton-associated (Arc\/Arg3.1) protein in the clinical identification of children with autism. <b><i>Subjects and Methods:<\/i><\/b> The plasma levels of Arc\/Arg3.1 in 62 boys with autism and 32 healthy boys were measured using an enzyme-linked immunosorbent assay (ELISA). The Childhood Autism Rating Scale (CARS) was used to assess the severity of autism as defined in the<b> <\/b>Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). The Mann-Whitney U test was used for comparisons between children with autism and healthy children. The Spearman r correlation coefficient (r) was used to determine the relationship between the CARS scores among patients with autism and different variables. <b><i>Results:<\/i><\/b> The mean plasma level of Arc\/Arg3.1 protein in autism was 1.689 \u00b1 0.917 pg\/ml, significantly higher than that of healthy controls, i.e. 0.792 \u00b1 1.056 pg\/ml (p < 0.001). No significant relationship was found between plasma levels of Arc\/Arg3.1 protein and CARS scores (r = -0.06; p > 0.05) or age (r = -0.27; p > 0.05). <b><i>Conclusions:<\/i><\/b> The mean plasma level of Arc\/Arg3.1 protein was higher in children with autism than in controls, suggesting that Arc\/Arg3.1 could be a potential early blood biomarker for diagnosis of autism.<\/jats:p>","DOI":"10.1159\/000445351","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T22:01:33Z","timestamp":1457733693000},"page":"350-354","source":"Crossref","is-referenced-by-count":20,"title":["Activity-Regulated Cytoskeleton-Associated Protein Dysfunction May Contribute to Memory Disorder and Earlier Detection of Autism Spectrum Disorders"],"prefix":"10.1159","volume":"25","author":[{"given":"Abdulrahman Mohammed","family":"Alhowikan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-54"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.14.21"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531512"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90299-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.05.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3429"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.08.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.024"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.06.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.04.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000354295"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408436"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3340-04.2004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1133"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.108"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301559"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025850431170"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00212-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4342-04.2005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2839"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80591-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.08.004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.28.021406.144007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(03)00189-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/nn1468"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:56:36Z","timestamp":1745430996000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,6,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000445351","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}