{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:02:24Z","timestamp":1778702544867,"version":"3.51.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Proteeae isolates displaying multidrug-resistance (MDR) are the second most common causes of hospital-associated infections. The aim of this study was to screen class 1-3 integrons and plasmid-mediated quinolone resistance (PMQR) genes in Proteeae isolates from the First Affiliated Hospital of the Wenzhou Medical University. <b><i>Materials and Methods:<\/i><\/b> 176 Proteeae isolates were collected from clinical specimens of inpatients between January 2011 and December 2013. Susceptibility testing was determined by the agar dilution method. Class 1-3 integrons and PMQR genes were amplified by polymerase chain reaction, and the variable regions of integrons were determined by restriction fragment length polymorphisms. <b><i>Results:<\/i><\/b> 68.2% Proteeae isolates exhibited MDR phenotypes: 46.6 and 10.8% Proteeae isolates were positive for <i>intI1 <\/i>and <i>intI2<\/i>, respectively. The resistance rate of integron-positive isolates to aminoglycosides, fluoroquinolones, and trimethoprim\/sulfamethoxazole was significantly higher than integron-negative isolates. Sequence analysis revealed that <i>dfrA1-sat2-aadA1, dfrA1-catB2-sat2-aadA1, <\/i>and<i> sat2-aadA1 <\/i>were first detected in <i>Morganella morganii <\/i>strains isolated from China. PMQR was determined by <i>qnrD<\/i> in 40 strains (22.7%). <b><i>Conclusion:<\/i><\/b> Our results indicate that class 1 and 2 integrons are common among Proteeae isolates. Meanwhile, <i>qnrD<\/i> are highly prevalent in Proteeae isolated from our hospital.<\/jats:p>","DOI":"10.1159\/000445426","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T22:57:46Z","timestamp":1464130666000},"page":"12-18","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Integrons and <b><i>qnr<\/i><\/b> Genes in Proteeae<b> <\/b>from a Teaching Hospital in China"],"prefix":"10.1159","volume":"62","author":[{"given":"Jianming","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiru","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.534-546.2000"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-16-3-317"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1586\/eri.13.1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03954.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01831-10"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-7646(98)80026-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.11.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/518167"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.723-726.2001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.185"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1823-1829.2005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047636"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2006.09.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.06.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00033-09"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2014.11.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2014.0147"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03312"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.041970-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2013-0893"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-13-510"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl549"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2012.02923.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt456"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2011.03059.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-12-1097"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.10.2911-2914.2000"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2012.0146"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:57:30Z","timestamp":1745431050000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,25]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000445426","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,25]]}}}