{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:52Z","timestamp":1787017912935,"version":"build-2736575974"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Limited mouth opening (LMO) is a frequent complication of systemic sclerosis (SS). Its management is complex and there are limited treatment options. We report four patients with SS and severe LMO [interincisal distance (IID) &lt;30 mm] treated with pulsed carbon dioxide (CO&lt;sub&gt;2&lt;\/sub&gt;) laser. Pulsed CO&lt;sub&gt;2&lt;\/sub&gt; laser treatment of the white lips was performed after all patients had signed a written informed consent in the absence of alternative treatment. Treatment was carried out under locoregional anaesthesia using a Sharplan 30C CO&lt;sub&gt;2&lt;\/sub&gt; laser in the Silk Touch\u00ae resurfacing mode. One to three laser sessions were performed at intervals of 8-12 months between sessions. Assessments were performed at 3 and 12 months with measurement of the IID using a ruler, calculation of the Mouth Handicap in Systemic Sclerosis (MHISS) scale and global evaluation by the patients. Adverse events were also reported. In all four patients, an improvement in IID occurred 3 months after the first session with a mean gain of +5 mm (range: 2-7). At 12 months, a mean gain of +8.5 mm (range: 7-10) in IID was observed. The MHISS score decreased by a mean of -14 (range: 11-17). All patients showed improvement of lip flexibility or mouth opening, allowing better phonation and mastication and easier dental care. Adverse effects were transient erythema and\/or dyschromia. CO&lt;sub&gt;2&lt;\/sub&gt; laser appears to be effective and well tolerated in the improvement of LMO in SS.<\/jats:p>","DOI":"10.1159\/000445821","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T18:57:42Z","timestamp":1464116262000},"page":"142-150","source":"Crossref","is-referenced-by-count":21,"title":["Improvement of Microstomia in Scleroderma after Carbon Dioxide Laser Treatment"],"prefix":"10.1159","volume":"8","author":[{"given":"Imane","family":"Bennani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carle","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-6868","authenticated-orcid":false,"given":"Cristina","family":"Bulai Livideanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2010.540250"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20480"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04199.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.09.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00679.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34259.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2011.587589"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.070532"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1383-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61252-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/art.38897"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.668"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0996-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-003-0216-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90309-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.672744"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3727\/096368913X674062"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445821","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:02:01Z","timestamp":1745416921000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000445821","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}