{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:01Z","timestamp":1745469181906,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; &lt;sup&gt;123&lt;\/sup&gt;I-iomazenil (IMZ) single-photon emission computed tomography (SPECT) is a tool for evaluating epileptic foci and brain damage. To apply the method to children, information regarding the age-specific expression of benzodiazepine receptors (BDZ-Rs) is required. Unfortunately, there is no information currently available for children &lt;2 years of age. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We used IMZ SPECT once in infants aged 3-8 months and again at 2 years of age in order to describe the maturational changes in BDZ-R distribution. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; No neurological deficits were found in any of the infants at the first examination. The BDZ-Rs were more dominantly distributed in the occipital lobe than in the frontal lobe before the age of 2 years. The frontal-occipital gradients of the distribution were obvious in children &lt;8 months of age. Magnetic resonance imaging showed a spreading of myelination toward the frontal lobes simultaneously with BDZ-R expression. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Information regarding the alteration in the BDZ-R distribution pattern is useful when assessing infantile epilepsy and brain injury. The age-related pattern of BDZ-R distribution could correspond with myelination, cerebral blood flow, metabolism and behavioral development.<\/jats:p>","DOI":"10.1159\/000445903","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T21:08:38Z","timestamp":1463605718000},"page":"244-248","source":"Crossref","is-referenced-by-count":1,"title":["Unique Distribution of Benzodiazepine Receptors in the Brain during the First Two Years of Life"],"prefix":"10.1159","volume":"51","author":[{"given":"Sadahiro","family":"Nomura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Suehiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Kiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyasu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.13.3.8316668"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1003.abs"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.3945811"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220408"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/fn.74.3.F153"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052419"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.75"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.04.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.05401.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340511"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.12.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1961.tb01032.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0370-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2106-10.2011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2174\/157015908783769653"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445903","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/445903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:02:53Z","timestamp":1745431373000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000445903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,7,14]]},"published-print":{"date-parts":[[2016,7,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000445903","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"type":"print","value":"1016-2291"},{"type":"electronic","value":"1423-0305"}],"subject":[],"published":{"date-parts":[[2016]]}}}