{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:14:57Z","timestamp":1788326097691,"version":"build-2803163510"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>After cessation of successful initial acne therapy, patients often experience flares. Consecutive maintenance treatment after successful induction therapy is promoted by guidelines; however, little is known about the efficacy\/safety of different maintenance regimens. A systematic review on acne maintenance treatments was conducted. We identified 5 randomized controlled trials [RCTs; adapalene vs. vehicle or vs. no treatment (3 RCTs), adapalene\/benzoyl peroxide (BPO) vs. vehicle, combination\/monotherapy of minocycline (systemic)\/tazarotene\/placebo] and 3 non-RCTs on systemic isotretinoin, adapalene\/BPO and azelaic acid. The results of adapalene versus vehicle\/no treatment varied depending on the reported outcome. The \u2018number of patients maintaining at least 50% improvement' counting inflammatory lesions\/non-inflammatory lesions with adapalene was superior to vehicle (risk ratio, RR 1.24, 95% confidence interval, CI 1.08-1.43\/RR 1.34, 95% CI 1.18-1.59). However, no significant differences were found in 2 of 3 RCTs for maintaining \u2018clear\/almost clear' or \u2018mild acne' or on the global grading score. For the combination regimens of minocycline\/tazarotene\/placebo, no significant differences were found. Adapalene\/BPO was superior to vehicle counting inflammatory lesions\/non-inflammatory lesions (RR 1.61, 95% CI 1.31-1.99; RR 1.80, 95% CI 1.44-2.26). Due to the scarcity of studies, few conclusions can be drawn. More homogeneous outcome measures and specific maintenance study designs may lead to more robust findings.<\/jats:p>","DOI":"10.1159\/000446069","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T21:15:58Z","timestamp":1464210958000},"page":"371-380","source":"Crossref","is-referenced-by-count":7,"title":["How Much Do We Know about Maintaining Treatment Response after Successful Acne Therapy? Systematic Review on the Efficacy and Safety of Acne Maintenance Therapy"],"prefix":"10.1159","volume":"232","author":[{"given":"Corinna","family":"Dressler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Rosumeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00357.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12885"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410021702"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.5.597"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.5.605"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10344.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000350820"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2005.04279.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:04:30Z","timestamp":1745431470000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,6,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000446069","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3995757","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}