{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:31:34Z","timestamp":1760189494687,"version":"3.40.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Chronic eosinophilic leukaemia associated with the &lt;i&gt;FIP1L1-PDGFRA&lt;\/i&gt; fusion gene (F\/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical presentations are heterogeneous with a higher incidence of eosinophil-mediated cardiomyopathy than in other hypereosinophilic syndrome variants. Features of chronic myeloproliferative disease are often present, including splenomegaly and elevated serum vitamin B&lt;sub&gt;12&lt;\/sub&gt; levels. The diagnosis is made by fluorescence in situ hybridization (FISH) showing the deletion of the &lt;i&gt;CHIC2&lt;\/i&gt; locus and\/or RT-PCR showing the &lt;i&gt;FIP1L1-PDGFRA&lt;\/i&gt; fusion transcript. Treatment with imatinib mesylate, a tyrosine kinase inhibitor, results in rapid and complete resolution of hypereosinophilia and associated symptoms, except for those related to sub-endocardial fibrosis that may be irreversible. We report the case of a male patient in whom isolated intractable cough remained the only clinical manifestation of F\/P+ CEL for 4 years. Furthermore, eosinophil autofluorescence, an as yet unreported artefact in this setting, precluded the detection of the &lt;i&gt;CHIC2&lt;\/i&gt; deletion and further delayed diagnosis, underlining that both FISH and RT-PCR should be performed when this disease is suspected.<\/jats:p>","DOI":"10.1159\/000446076","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T21:04:21Z","timestamp":1463000661000},"page":"374-379","source":"Crossref","is-referenced-by-count":4,"title":["Severe Prolonged Cough as Presenting Manifestation of &lt;b&gt;&lt;i&gt;FIP1L1-PDGFRA&lt;\/i&gt;&lt;\/b&gt;+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association"],"prefix":"10.1159","volume":"91","author":[{"given":"Florence","family":"Roufosse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Sidon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-0955","authenticated-orcid":false,"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24196"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2393"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182a71eba"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.135251"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00089405"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01467.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/974609"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.060196"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2009.10.088"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000050518"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.12.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808991"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-013-9543-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446076","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:04:32Z","timestamp":1745431472000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,6,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000446076","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2016]]}}}