{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:11:34Z","timestamp":1781007094696,"version":"3.54.1"},"reference-count":50,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;Background: &lt;\/b&gt;Population migrations and overseas recreational travel to regions at risk for tropical diseases are increasing. A major challenge in non-endemic countries is to decrease the number of blood donor deferrals due those tropical disease pathogens, without compromising the high level of blood safety. The protozoans &lt;i&gt;Trypanosoma cruzi &lt;\/i&gt;and &lt;i&gt;Plasmodium &lt;\/i&gt;spp., the causative organisms of Chagas disease (CD) and malaria are becoming a major focus in the blood transfusion community. &lt;b&gt;Methods: &lt;\/b&gt;National guidelines of the Blood Transfusion Service of the Swiss Red Cross propose an algorithm for dealing with these pathogens, including a mandatory selective serological testing of donors at risk. &lt;b&gt;Results:&lt;\/b&gt; 6,978 donors at risk for CD were tested. Three of them were confirmed &lt;i&gt;anti-T. cruzi&lt;\/i&gt;-positive, and in one case a transfusion-transmitted infection was highly possible. The specificity of the assay was 99.94%. For malaria 12,887 donors were at risk and 178 were confirmed positive. The specificity of the assays was 92.8%. &lt;b&gt;Conclusion: &lt;\/b&gt;CD and malaria in non-endemic countries may represent a certain risk for blood transfusion. Switzerland chose a selective testing approach. The specificity of the assays is a crucial topic for this approach because it ensures a minimal loss of false-reactive donors and helps towards an easier counselling of implicated donors.<\/jats:p>","DOI":"10.1159\/000446218","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T21:01:29Z","timestamp":1462222889000},"page":"169-176","source":"Crossref","is-referenced-by-count":12,"title":["Selective Testing of At-Risk Blood Donors for Trypanosoma cruzi and Plasmodium spp. in 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