{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:11:22Z","timestamp":1780618282396,"version":"3.54.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Objectives: Analysis of a large local autopsy collective to gather epidemiological and histopathological data on hepatocellular carcinoma (HCC). Methods: We examined a large dataset of 44,104 autopsies performed at the Institute of Pathology, Basel, Switzerland, including 2 autopsy collectives (1969-1983 and 1988-2012) to gather current data on HCC in the advanced stage. A total of 398 HCC were diagnosed, accounting for around 1% of all autopsies. Results: As expected, most patients developing HCC had advanced stages of liver fibrosis or cirrhosis (F3\/F4). However, in the more recent autopsy collective (1988-2012), our data also show an increase of HCC arising in livers without or with only mild to moderate fibrosis (F0-F2). Extrahepatic metastasis was found in 156 of 398 HCC (39.1%), with lung metastasis (74.5%) being the most common, followed by the bones (24.8%) and adrenal glands (19.1%). Conclusions: Our data therefore seem to suggest that, in the last 2 decades, despite the introduction of new therapeutic modalities for HCC, no significant changes have been observed regarding the metastatic pattern of advanced HCC.<\/jats:p>","DOI":"10.1159\/000446245","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T21:04:39Z","timestamp":1466456679000},"page":"301-307","source":"Crossref","is-referenced-by-count":30,"title":["Clinicopathological Features and Metastatic Pattern of Hepatocellular Carcinoma: An Autopsy Study of 398 Patients"],"prefix":"10.1159","volume":"83","author":[{"given":"Manuel","family":"Schlageter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Quagliata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Matter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Perrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tornillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9393-9660","authenticated-orcid":false,"given":"Luigi","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00168.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61347-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090711-163752"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22312"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb01478.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830301)51:5<863::AID-CNCR2820510520>3.0.CO;2-D"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.08.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12925"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800682"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i43.15955"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100618"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032359"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.037"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/604860"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22734"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)76249-8"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pat\/article-pdf\/83\/6\/301\/3926362\/000446245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pat\/article-pdf\/83\/6\/301\/3926362\/000446245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:05:38Z","timestamp":1745431538000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,8,3]]},"published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000446245","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}