{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:52Z","timestamp":1787017912979,"version":"build-2736575974"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; A &lt;sup&gt;1&lt;\/sup&gt;H-NMR-derived metabolomic index based on early umbilical cord blood alterations of succinate, glycerol, 3-hydroxybutyrate and O-phosphocholine has shown potential for the prediction of hypoxic-ischaemic encephalopathy (HIE) severity. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate whether this metabolite score can predict 3-year neurodevelopmental outcome in infants with perinatal asphyxia and HIE, compared with current standard biochemical and clinical markers. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From September 2009 to June 2011, infants at risk of perinatal asphyxia were recruited from a single maternity hospital. Cord blood was drawn and biobanked at delivery. Neonates were monitored for development of encephalopathy both clinically and electrographically. Neurodevelopmental outcome was assessed at 36-42 months using the Bayley Scales of Infant and Toddler Development, ed. III (BSID-III). Death and cerebral palsy were also considered as abnormal end points. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Thirty-one infants had both metabolomic analysis and neurodevelopmental outcome at 36-42 months. No child had a severely abnormal BSID-III result. The metabolite index significantly correlated with outcome (&amp;#x03C1;&lt;sup&gt;2&lt;\/sup&gt; = 0.30, p &lt; 0.01), which is robust to predict both severe outcome (area under the receiver operating characteristic curve: 0.92, p &lt;i&gt;&lt; &lt;\/i&gt;0.01) and intact survival (0.80, p = 0.01). There was no correlation between the index score and performance in the individual BSID-III subscales (cognitive, language, motor). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The metabolite index outperformed other standard biochemical markers at birth for prediction of outcome at 3 years, but was not superior to EEG or the Sarnat score.<\/jats:p>","DOI":"10.1159\/000446556","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T17:01:32Z","timestamp":1470157292000},"page":"296-302","source":"Crossref","is-referenced-by-count":33,"title":["Early Cord Metabolite Index and Outcome in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy"],"prefix":"10.1159","volume":"110","author":[{"given":"C.E.","family":"Ahearne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Denihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.H.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.C.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.","family":"Boylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.I.","family":"Broadhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.206"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1524"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12900"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2013.04.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603073341001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6640.24"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303692"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.100800"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.042"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12306"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-52"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.03.032"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/720514"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1039\/b906712b"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/254076"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1021\/pr400617m"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00517-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2190"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.05.040"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009606"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.88"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(00)00128-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600543"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302970"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446556","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:09:03Z","timestamp":1745417343000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,11,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000446556","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}