{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:32:38Z","timestamp":1789957958753,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Congenital cytomegalovirus (cCMV) can cause brain inflammation\/destruction and teratogenic effects. The only validated neuroimaging prognostic categorization for symptomatic cCMV available is based on destructive lesions seen on computed tomography (CT). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to establish the predictive ability of a comprehensive neonatal neuroimaging scale in symptomatic cCMV. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Twenty-six infants were studied by neonatal cranial ultrasound scans (US; n = 25), CT (n = 11) and magnetic resonance imaging (MRI; n = 9). A previously validated neuroimaging scale comprising calcifications, ventriculomegaly and atrophy was compared to a newly proposed system adding cerebral dysgenesis and white matter disease. The findings were graded from 0 to 3. Neurodevelopmental assessment included motor and cognitive functions, epilepsy, vision, hearing and behavioral disorders. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both scales showed a significant association with outcome (p &lt; 0.005). Our scale was more accurate in predicting death or moderate-severe disability (area under the curve for scores \u22652, 0.88 \u00b1 0.06 vs. 0.80 \u00b1 0.08). All 5 infants with normal neuroimaging survived with intact neurological function. While our scale was highly associated with outcome in patients studied by MRI, it was unable to predict unfavorable outcomes in 2 patients with mildly abnormal US and\/or CT. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A comprehensive scale based on US and MRI predicts neurodevelopment in symptomatic cCMV. Significant destructive lesions are associated with a poor prognosis. While a strictly normal cranial US predicts a favorable outcome, in case of subtle US abnormalities, MRI is crucial for prognostication.<\/jats:p>","DOI":"10.1159\/000446690","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T17:01:32Z","timestamp":1466787692000},"page":"277-285","source":"Crossref","is-referenced-by-count":88,"title":["A Prognostic Neonatal Neuroimaging Scale for Symptomatic Congenital Cytomegalovirus Infection"],"prefix":"10.1159","volume":"110","author":[{"given":"Ana","family":"Alarcon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Martinez-Biarge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Caba\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Quero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Garc\u00eda-Alix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.409"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815833"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-011-2120-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.03.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000375439"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0160-x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2302021459"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1695-4033(04)78299-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.12.900"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00695.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20071"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.08.012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404599"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.208405"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13053"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308357"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(96)00170-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00088-8"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446690","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:10:25Z","timestamp":1745417425000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,11,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000446690","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}