{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:51:21Z","timestamp":1784134281939,"version":"3.55.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Darier disease\/dyskeratosis follicularis is a genodermatosis characterized by brown, oily keratotic papules and plaques in the seborrheic areas of the face and chest. Responsible for the disease are mutations in the &lt;i&gt;ATP2A2&lt;\/i&gt; gene, encoding SERCA2, a calcium pump of the sarco-\/endoplasmic reticulum. Mechanical trauma, heat, humidity, ultraviolet B radiation, oral corticosteroids and lithium are known trigger factors of the disorder. We report on a 48-year-old German woman with a flare-up of Darier disease under interferon-\u03b1-2a (IFN\u03b1-2a) therapy with clinical signs of lichen nitidus. Due to the fulminant course of the eruption, we suspected IFN\u03b1 as a possible trigger. To our knowledge there are no reports regarding exacerbation of Darier disease during IFN\u03b1 therapy. Possible pathogenetic mechanisms are being discussed.<\/jats:p>","DOI":"10.1159\/000446693","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T21:02:00Z","timestamp":1471381320000},"page":"218-223","source":"Crossref","is-referenced-by-count":7,"title":["Exacerbation of Darier Disease under Interferon-\u03b1-2a Therapy with Clinical Signs of Lichen Nitidus"],"prefix":"10.1159","volume":"8","author":[{"given":"Ioannis","family":"Karagiannidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos\u00a0C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3605"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700091"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893419"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12111"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050388"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.149"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.468"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.10.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12273"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:10:28Z","timestamp":1745431828000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,16]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000446693","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,16]]}}}