{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:58:42Z","timestamp":1784973522154,"version":"3.55.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;Background:&lt;\/b&gt; Granulocyte-colony stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSCs) in healthy donors. A few reports have shown that some healthy donors developed acute respiratory distress syndrome or capillary leak syndrome after more than several rounds of G-CSF administration or leukapheresis. &lt;b&gt;Case Report:&lt;\/b&gt; We report the case of a healthy donor for allogeneic stem cell transplantation who developed severe hypoxemia 1 h after only the first administration of G-CSF. The donor was administered 10 \u03bcg\/kg G-CSF (lenograstim) subcutaneously for PBSC mobilization. 1 h after the first administration of G-CSF, the donor suddenly presented with dry cough and dyspnea. The oxygen saturation by pulse oximetry (SpO&lt;sub&gt;2&lt;\/sub&gt;) in the room air was 88%. An electrocardiogram and chest radiography revealed no abnormalities. We excluded other causes of severe hypoxemia and diagnosed the donor with hypoxemia due to G-CSF administration, which was subsequently terminated. The donor was administered 2 l\/min oxygen via a nasal cannula and 100 mg hydrocortisone intravenously. He subsequently recovered, and SpO&lt;sub&gt;2&lt;\/sub&gt; in the room air returned to 98% 10 h after hypoxemia. &lt;b&gt;Conclusion:&lt;\/b&gt; These respiratory symptoms might be related to anaphylactoid or hypersensitivity reaction. The donors should be observed for at least 1 h after the first administration of G-CSF.<\/jats:p>","DOI":"10.1159\/000446814","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T21:09:43Z","timestamp":1476824983000},"page":"433-435","source":"Crossref","is-referenced-by-count":9,"title":["Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor"],"prefix":"10.1159","volume":"43","author":[{"given":"Keita","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-3179","authenticated-orcid":false,"given":"Noriko","family":"Doki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Senoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-0021","authenticated-orcid":false,"given":"Yuho","family":"Najima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Kakihana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Haraguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuteru","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-417667"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000354196"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2008.05.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1695"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703138"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.10.872"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108223250818"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00423-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701547"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.438"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12149"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00700.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001611"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1716"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:16Z","timestamp":1745431876000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000446814","archive":["Portico"],"relation":{},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}