{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:10:34Z","timestamp":1780395034824,"version":"3.54.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Exposure to aristolochic acid (AA) can cause AA nephropathy, which is characterized by extensive proximal tubular damage and polyuria. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; To test the hypothesis that polyuria might be induced by altered regulation of aquaporins (AQPs) in the kidney, different doses of AA-I or aristolactam I (AL-I) were administered intraperitoneally to Sprague-Dawley rats, and urine, blood, and kidney samples were analyzed. In addition, AQP1, AQP2, AQP4 and AQP6 expression in the kidney were determined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The results showed dose-dependent proximal tubular damage and polyuria in the AA-I- and AL-I-treated groups, and the nephrotoxicity of AL-I was higher than that of AA-I. The expression of renal AQP1, AQP2 and AQP4, but not AQP6 were significantly inhibited by AA-I and AL-I. Comparison of the inhibition potencies of AA-I and AL-I showed that AL-I was a stronger inhibitor of AQP1 expression than AA-I, while there was no difference in their effects on AQP2 and AQP4. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; These results suggested that AA induced renal damage and polyuria were associated with a specific decrease in the expression of renal AQP1 AQP2 and AQP4, and AL-I showed higher nephrotoxicity than AA-I, which might be attributable to the differences in their inhibition of AQP1.<\/jats:p>","DOI":"10.1159\/000446854","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T09:23:34Z","timestamp":1467192214000},"page":"213-221","source":"Crossref","is-referenced-by-count":18,"title":["Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity"],"prefix":"10.1159","volume":"133","author":[{"given":"Ji","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhenZhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiuQin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LuYong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431713"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92984-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.129"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050537"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.05.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002714"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.565"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-006-0090-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.707"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2010.03.012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.253"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00365590310008811"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.389"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5808"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2003.00232.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.22.1.3818"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00216.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0470-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr291"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00621.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.12.128"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01636-6"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446854","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:47:12Z","timestamp":1745412432000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,7,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000446854","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727298510.793528606","asserted-by":"object"}]},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}