{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:57:01Z","timestamp":1791863821637,"version":"4.3.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Immunological and vascular markers may play a role in the pathophysiology of mood disorders and mood changes. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To test whether the cell adhesion molecule soluble intracellular adhesion molecule-1 (sICAM-1) may serve as a biomarker for patients with unipolar or bipolar affective disorders when compared to a healthy control group, and whether sICAM-1 blood levels change during different mood states. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; sICAM-1 serum concentrations were compared between 20 healthy controls and 48 patients with affective disorders (unipolar, bipolar II and bipolar I disorder) during different mood states (euthymic mood state, depression or mania). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; When compared to healthy controls, patients with affective disorders had significantly higher sICAM-1 levels during the euthymic state (p = 0.015). Differences became more pronounced during depression (p = 0.013). When unipolar and bipolar patients were analyzed separately, unipolar patients significantly differed from controls during the euthymic and depressive mood state, while bipolar II patients showed a trend towards higher sICAM-1 levels during depression. Patients with bipolar I disorders had significantly higher sICAM-1 levels during manic states when compared to controls (p = 0.007). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; sICAM-1 elevation in unipolar and bipolar patients, independent of mood changes, might support the hypothesis of chronic immune activation and endothelial dysfunction in patients with affective disorders.<\/jats:p>","DOI":"10.1159\/000446919","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T21:01:23Z","timestamp":1469134883000},"page":"8-14","source":"Crossref","is-referenced-by-count":22,"title":["Soluble Intracellular Adhesion Molecule-1 in Patients with Unipolar or Bipolar Affective Disorders: Results from a Pilot Trial"],"prefix":"10.1159","volume":"74","author":[{"given":"Martin","family":"Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Friebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.06.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000049007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb01727.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90023-R"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1592"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.2.271"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.02.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1682"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2006.00480.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000031"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-007-0189-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318202bc42"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4161\/viru.24530"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.07.011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.2.157"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002043"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.02.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.052"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.5.723"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/03014460110048530"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710001984"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0323-x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-013-0387-y"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446919","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:12Z","timestamp":1745426892000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000446919","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}