{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:14:58Z","timestamp":1785867298189,"version":"3.56.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Immediate allergic reactions to \u03b2-lactam antibiotics are considered to be one of the most important drug hypersensitivities. A positive skin test (ST) with a combination of major and minor penicillin determinants is usually sufficient to recommend avoidance of the culprit drug, whereas a negative ST is usually followed by an oral challenge test (OCT). Recently, concern has been raised regarding the role of amoxicillin (AMX) ST in the diagnosis of AMX allergy. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to examine the additive value of AMX determinants in STs of patients with immediate hypersensitivity reactions to AMX or AMX-clavulanate (AMX-C). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients with a history of immediate AMX or AMX-C allergy underwent an ST using a combination of penicilloyl-polylysine (PPL) and minor determinants as well as AMX. An ST with AMX-C was added when appropriate. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Thirty-one patients were evaluated. Eight patients, all of them with a history of AMX allergy, had positive reactions only to the AMX component. Two patients with AMX-C allergy had a positive ST reaction only to the AMX-C component. Moreover, only 14 patients (13 with AMX and 1 with AMX-C allergy) had a positive reaction to PPL, whereas most patients (54.8%) had positive reactions to other determinants. One patient, who was positive for AMX, developed several urticarial lesions after the test. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Skin testing with AMX and AMX-C is mandatory in patients with immediate allergy to these drugs. Failure to perform it may result in a false-negative ST jeopardizing these patients with anaphylactic reactions during a hazardous OCT.<\/jats:p>","DOI":"10.1159\/000446961","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T21:42:34Z","timestamp":1467927754000},"page":"62-66","source":"Crossref","is-referenced-by-count":23,"title":["The Importance of Amoxicillin and Amoxicillin-Clavulanate Determinants in the Diagnosis of Immediate Allergic Reactions to \u03b2-Lactams"],"prefix":"10.1159","volume":"170","author":[{"given":"Ronit","family":"Confino-Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Rosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idit","family":"Lachover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Meir Shafrir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0476-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00175.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000065876"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00678.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.01.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01916.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02110.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00089.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000173"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.02.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.045"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90064-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1988.tb02904.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510200062033"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/all.12636"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90105-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02867.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01874.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.04.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62539-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.032"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12689"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446961","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/446961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:48Z","timestamp":1745426928000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000446961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000446961","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}