{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:08Z","timestamp":1792099808398,"version":"4.4.0"},"reference-count":219,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later. They encompass gastrointestinal symptoms (nausea, diarrhea, gastric bleeding, dyspepsia), hepatotoxicity, weight gain and metabolic abnormalities, cardiovascular disturbances (heart rate, QT interval prolongation, hypertension, orthostatic hypotension), genitourinary symptoms (urinary retention, incontinence), sexual dysfunction, hyponatremia, osteoporosis and risk of fractures, bleeding, central nervous system disturbances (lowering of seizure threshold, extrapyramidal side effects, cognitive disturbances), sweating, sleep disturbances, affective disturbances (apathy, switches, paradoxical effects), ophthalmic manifestations (glaucoma, cataract) and hyperprolactinemia. At times, such adverse events may persist after drug discontinuation, yielding iatrogenic comorbidity. Other areas of concern involve suicidality, safety in overdose, discontinuation syndromes, risks during pregnancy and breast feeding, as well as risk of malignancies. Thus, the rational selection of ADs should consider the potential benefits and risks, likelihood of responsiveness to the treatment option and vulnerability to adverse events. The findings of this review should alert the physician to carefully review the appropriateness of AD prescription on an individual basis and to consider alternative treatments if available.<\/jats:p>","DOI":"10.1159\/000447034","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T17:01:59Z","timestamp":1470848519000},"page":"270-288","source":"Crossref","is-referenced-by-count":580,"title":["The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature"],"prefix":"10.1159","volume":"85","author":[{"given":"Andr\u00e9 F.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu S.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6310-3571","authenticated-orcid":false,"given":"Andr\u00e9 R.","family":"Brunoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A.","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2011.11.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030442"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.05.097"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.224"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000086"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05528blu"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A254"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00092-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.12.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150630175044"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d8300"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60046-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0267-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-011-0259-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-10-200811180-00008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150630174343"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.06.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002791"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.2.022305.095301"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2000.tb10944.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093582"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113492027"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835bc703"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04351.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00413"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.061960"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12111467"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199707)6:4<235::AID-PDS293>3.0.CO;2-3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920030-00007"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0169-z"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S54710"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-015-0001-y"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S87968"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13050709"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26208"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12988"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.828032"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/s40303-015-0011-7"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.07.003"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.11.014"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1270"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05346blu"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00018-9"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.25"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1159\/000209349"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.07.026"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.71"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.042"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02885.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.4.523"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20204"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32835a4206"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08071065"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1187"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv153"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.016"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2393"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.008"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1565204"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.05.011"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13121605"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.2147\/nedt.2007.3.2.193"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714001767"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2010.04.006"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14027ah1"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013501994"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.11.001"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13r08672"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000155815.44338.95"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200108000-00019"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200926050-00002"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00385-X"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000204328.50105.b3"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/01.HDX.0000061695.97215.64"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831050-00002"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00754-4"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1007\/s001920070009"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200825070-00001"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900026729"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2014.03.2744"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a5233f"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.05.009"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0124-z"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1080\/00926230802096390"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2013.04.art22"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0129-4"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1080\/00048670903107575"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199807006-00001"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000198"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.951324"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00313-5"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.11.003"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666140612112630"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1159\/000091777"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.01.010"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815509"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4551"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001192"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G293"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1554"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000292"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.2174\/1566524016666160126144303"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.05.003"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1778-8"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9099-9"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05786blu"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.2165\/11589340-000000000-00000"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2015-102212"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.06.021"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.82"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S45445"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.7.795"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002022"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.128"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7516.529"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1002\/hup.918"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015594812"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200203000-00006"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199710000-00007"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250091"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000203200.96205.34"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a39101"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041867"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120037428"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1080\/15563650601118101"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0560-3"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv082"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666141130203823"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000227699.26375.f8"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.024"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7251-9"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1350"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E564"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831020-00002"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.5.874-a"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950140063009"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.12.007"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565070-00003"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.05.001"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.02.006"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n0803"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.04.100173"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.051110"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0047-3"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj043"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01514.x"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1159\/000358808"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1159\/000345316"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1002\/da.20438"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1159\/000362803"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0620"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2015.1117111"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08744"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1080\/10673220701551102"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1411138"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.1159\/000442293"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.2.207"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.150"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i65"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1053"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.06.003"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00234-2"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.070219"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1007\/BF03161207"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.1177\/2045125315612334"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.1159\/000370338"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.1159\/000439137"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1159\/000371865"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109359094"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2429"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1159\/000362317"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418080-00001"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701815"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2180"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002041"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10038"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.2165\/11533180-000000000-00000"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.11.042"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.03.006"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.2.8344205"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.2165\/11595660-000000000-00000"},{"key":"ref183","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.08.008"},{"key":"ref184","doi-asserted-by":"publisher","DOI":"10.1177\/2045125313490305"},{"key":"ref185","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2009.07.006"},{"key":"ref186","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.13070147"},{"key":"ref187","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000116689.75396.5f"},{"key":"ref188","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12r07968"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12479"},{"key":"ref190","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002166"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12r07966"},{"key":"ref192","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4877"},{"key":"ref193","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3190"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6932"},{"key":"ref195","doi-asserted-by":"publisher","DOI":"10.1002\/hup.696"},{"key":"ref196","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1798"},{"key":"ref197","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2473"},{"key":"ref198","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.027"},{"key":"ref199","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.02.015"},{"key":"ref200","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0233-3"},{"key":"ref201","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17865-9"},{"key":"ref202","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181a58fb4"},{"key":"ref203","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200620030-00002"},{"key":"ref204","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000007"},{"key":"ref205","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67288-4"},{"key":"ref206","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018210"},{"key":"ref207","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2307-y"},{"key":"ref208","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.09.009"},{"key":"ref209","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12059"},{"key":"ref210","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.647684"},{"key":"ref211","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29714"},{"key":"ref212","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1827"},{"key":"ref213","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31817e0ecb"},{"key":"ref214","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.10.014"},{"key":"ref215","doi-asserted-by":"publisher","DOI":"10.1159\/000438780"},{"key":"ref216","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260250028021"},{"key":"ref217","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0910"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15040476"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1159\/000366041"}],"container-title":["Psychotherapy and Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pps\/article-pdf\/85\/5\/270\/3926381\/000447034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pps\/article-pdf\/85\/5\/270\/3926381\/000447034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:49:54Z","timestamp":1745412594000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":219,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,8,25]]},"published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000447034","archive":["Portico"],"relation":{},"ISSN":["0033-3190","1423-0348"],"issn-type":[{"value":"0033-3190","type":"print"},{"value":"1423-0348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}