{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:13:59Z","timestamp":1762506839617,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<b><i>Purpose:<\/i><\/b> Demyelinizing neurological disease is a rare complication after treatment with tumor necrosis factor (TNF)\u03b1 antagonists. We report on a case of multiple sclerosis after TNF\u03b1 antagonist treatment and discuss its differential diagnosis. <b><i>Methods:<\/i><\/b> This is an observational case study. <b><i>Results:<\/i><\/b> A 48-year-old male was referred to Ophthalmology in January 2015 for an absolute scotoma in the superior quadrant of the visual field in his right eye. Visual acuity was 20\/50 in the right eye and 20\/20 in the left. Fundus examination was unremarkable bilaterally. Spectral domain optical coherence tomography revealed a normal macular retina structure. Visual field examination revealed a superior hemianopsia in the right eye. Head magnetic resonance imaging showed findings compatible with optic neuritis. The visual evoked potentials confirmed the presence of optic neuritis. The patient had been under therapy with adalimumab since January 2014, for Crohn\u2019s disease. Suspension of adalimumab was recommended, and it was substituted with tapered deltacortene, from 1 mg\/kg\/day. After 1 month, the scotoma was resolved completely. <b><i>Conclusions:<\/i><\/b> TNF\u03b1 antagonists can provide benefit to patients with inflammatory autoimmune diseases. However, they can also be associated with severe adverse effects. Therefore, adequate attention should be paid to neurological abnormalities in patients treated with TNF\u03b1 antagonists.<\/jats:p>","DOI":"10.1159\/000447086","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T22:27:56Z","timestamp":1468276076000},"page":"345-353","source":"Crossref","is-referenced-by-count":8,"title":["Demyelinizing Neurological Disease after Treatment with Tumor Necrosis Factor-\u03b1 Antagonists"],"prefix":"10.1159","volume":"7","author":[{"given":"Claudia","family":"Bru\u00e8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Rossiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427050-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200401000-00004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21814"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<1977::AID-ART345>3.0.CO;2-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/art.10488"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200605000-00021"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199906)45:6<695::AID-ANA3>3.0.CO;2-R"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.111500"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(05)81044-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.994"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/815068"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-996-0020-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S28112"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:28Z","timestamp":1745427028000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000447086","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}