{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:19:47Z","timestamp":1783826387657,"version":"3.55.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; During the last decades many successful efforts have been made in order to increase life expectancy in ovarian cancer (OC) patients. However, just a few studies have investigated the impact of OC on quality of life (QoL) and sexual function in OC cases during treatment. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate the QoL and sexual function of OC patients during chemotherapy (CT). &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Forty-nine subjects were enrolled and filled in the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-OV28, Female Sexual Function Index (FSFI) and Female Sexual Distress Scale (FSDS) questionnaires. The results were evaluated globally and consequently stratified into several groups: single surgery versus multiple surgeries, age \u226448 years versus &gt;48 years, and first-line CT versus multiple lines of CT. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Menopause-related symptoms, body image and attitude toward the disease were significantly worse during first-line CT (p = 0.018, p = 0.029 and p = 0.006, respectively). Sexual outcomes resulted in better scores in younger patients in all questionnaires (FSFI: p = 0.001; FSDS: p = 0.048; specific EORTC QLQ-OV28 items: p = 0.022). Scores concerning body image, attitude toward the disease and CT-associated symptoms resulted worse in patients after the first surgery (p = 0.017, p = 0.002 and p = 0.012, respectively). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our study confirms that OC has a detrimental impact on QoL and intimacy, particularly in younger patients, during the first course of CT and after the first cytoreductive surgery.<\/jats:p>","DOI":"10.1159\/000447403","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T21:02:29Z","timestamp":1470949349000},"page":"205-210","source":"Crossref","is-referenced-by-count":26,"title":["Sexual Health and Quality of Life Assessment among Ovarian Cancer Patients during Chemotherapy"],"prefix":"10.1159","volume":"91","author":[{"given":"Lavinia","family":"Domenici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocenza","family":"Palaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Giorgini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio Piacentino","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Tomao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-5790","authenticated-orcid":false,"given":"Violante","family":"Di Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Perniola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Musella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Muzii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Benedetti Panici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181bf8143"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.03.033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/019394599701900305"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1188\/06.ONF.553-562"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00307-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/00926230290001448"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00437.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1356"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e318248d89d"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.2.148"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-77"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11253"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:52:54Z","timestamp":1745427174000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,10,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000447403","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}