{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:46:13Z","timestamp":1754261173876,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Intrauterine growth restriction is associated with arterial hypertension in adulthood; however, the underlying mechanism is unclear. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We hypothesized that serum insulin-like growth factor-1 (IGF-1) levels affect central aortic elastic properties and structure in small-for-gestational-age (SGA) infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eighteen SGA infants and 22 appropriate-for-gestational-age (AGA) infants were enrolled in this study. The serum IGF-1 level within 1 h of birth and abdominal aortic echo parameters at 1 week of age were retrospectively compared. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the SGA infants, IGF-1 levels (27.6 \u00b1 17.7 vs. 42.6 \u00b1 15 ng\/ml, p = 0.006), aortic strain (10.2 \u00b1 3.1 vs. 12.8 \u00b1 3.1%, p = 0.01), and aortic distensibility (0.73 \u00b1 0.19 vs. 0.92 \u00b1 0.34 cm&lt;sup&gt;2&lt;\/sup&gt;\/dyn \u00d7 10&lt;sup&gt;-4&lt;\/sup&gt;, p = 0.05) were significantly lower compared with AGA infants. By contrast, blood pressure, aortic intima-media thickness (aIMT) in relation to body weight (383 \u00b1 163 vs. 256 \u00b1 43 \u03bcm\/kg, p &lt; 0.001), aortic stiffness index in relation to body weight (2.0 \u00b1 1.7 vs. 1.1 \u00b1 0.4, p = 0.005), and arterial pressure-strain elastic modulus (293 \u00b1 72 vs. 242 \u00b1 78 mm Hg, p = 0.04) were higher compared with AGA infants. In the SGA infants, IGF-1 levels were significantly correlated with aortic strain (r = 0.49, p = 0.04), aIMT in relation to body weight (r = -0.61, p = 0.007), and aortic stiffness index in relation to body weight (r = -0.63, p = 0.005). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Decreased serum IGF-1 levels in SGA infants may affect the vascular compliance and structure of the central aorta.<\/jats:p>","DOI":"10.1159\/000447480","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T21:01:50Z","timestamp":1470862910000},"page":"30-36","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Decreased Serum Insulin-Like Growth Factor-1 Levels on Central Aortic Compliance in Small-for-Gestational-Age 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