{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:19:40Z","timestamp":1770527980066,"version":"3.49.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests assessing caregiver burden, functionality and cognition according to blood pressure (BP) variations and &lt;i&gt;APOE&lt;\/i&gt; haplotypes, while also taking into account differential effects of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, \u03b2-blockers, calcium channel blockers, diuretics, or no antihypertensive medication on score changes. The diagnosis and treatment of arterial hypertension followed the JNC 7 report. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Variations in systolic BP (-11.76 \u00b1 17.1 mm Hg), diastolic BP (-4.92 \u00b1 10.3 mm Hg) and pulse pressure (-6.84 \u00b1 12.6 mm Hg) were significant after 1 year (n = 191; &amp;#x03C1; &lt; 0.01). For APOE4+ carriers, rises in systolic or diastolic BP improved Clinical Dementia Rating Scale Sum of Boxes scores (&amp;#x03C1; &lt; 0.04), with marginally significant improvements in Mini-Mental State Examination scores resulting from risen systolic (&amp;#x03C1; = 0.069) or diastolic BP (&amp;#x03C1; = 0.079), and in basic independence only regarding risen diastolic BP (&amp;#x03C1; = 0.055). APOE4- carriers resisted any functional or cognitive effects of BP variations. No differences were found regarding any antihypertensive class for variations in BP or any test scores, regardless of &lt;i&gt;APOE&lt;\/i&gt; haplotypes. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Targeting mild BP elevations brings better functional and cognitive results for APOE4+ carriers with AD.<\/jats:p>","DOI":"10.1159\/000447585","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T22:27:57Z","timestamp":1468276077000},"page":"314-323","source":"Crossref","is-referenced-by-count":28,"title":["Associations of Blood Pressure with Functional and Cognitive Changes in Patients with Alzheimer's Disease"],"prefix":"10.1159","volume":"41","author":[{"given":"Fabricio Ferreira","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Suchi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia Cardoso","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Ferreira","family":"Bertolucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000316872"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.10.051"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000249146"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9738-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4094"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000045"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.04.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e3180335f9f"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462010005000002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000362926"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000431218"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2559"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31811ff2b4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2190\/UURL-2RYU-WRYD-EY3K"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2004000200004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.05.010"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.06.011"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000203365"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514522853"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.128744"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4477"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000230877"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132189"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5465"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a35228"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13627"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.10.015"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1590\/0101-60830000000015"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:54:35Z","timestamp":1745427275000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":34,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2016,8,5]]},"published-print":{"date-parts":[[2016,8,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000447585","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3482300","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}