{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:47:28Z","timestamp":1773798448719,"version":"3.50.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Many patients with chronic kidney disease are prescribed vitamin D receptor agonists (VDRAs) for the management of secondary hyperparathyroidism. Oral phosphate binders may interact with, and potentially reduce the therapeutic activity of, oral VDRAs. This post hoc analysis of a Phase 3 study evaluated the pharmacodynamic effects of the iron-based phosphate binder sucroferric oxyhydroxide (SFOH) and sevelamer (SEV) carbonate on VDRA activity in dialysis patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; One thousand and fifty nine patients were randomized to SFOH 1.0-3.0 g\/day (n = 710) or SEV 2.4-14.4 g\/day (n = 349) for up to 52 weeks. Potential interactions of SFOH and SEV with VDRAs were assessed using serum intact parathyroid hormone (iPTH) concentrations as a pharmacodynamic biomarker. Three populations of SFOH- and SEV-treated patients were analyzed: Population 1 (n = 187), patients taking concomitant stable doses of oral VDRAs only; Population 2 (n = 250), patients taking no concomitant VDRAs; Population 3 (n = 68), patients taking concomitant stable doses of intravenous paricalcitol only. Populations were compared using a mixed-effects model to obtain the least squares mean change in iPTH from baseline to Week 52. Differences between treatment groups were also compared. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In Population 1, iPTH decreased from baseline to Week 52 in the SFOH group (-25.3 pg\/ml) but increased in the SEV group (89.8 pg\/ml) (p = 0.02). In Population 2, iPTH increased to a similar extent in both treatment groups. In Population 3, iPTH concentrations in both treatment groups decreased to a similar degree (-29.6 and -11.4 pg\/ml for SFOH and SEV, respectively; p = 0.87). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In contrast with SEV, SFOH did not appear to impact the iPTH-lowering effect of oral VDRAs.<\/jats:p>","DOI":"10.1159\/000447600","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T21:02:16Z","timestamp":1468962136000},"page":"104-112","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients"],"prefix":"10.1159","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-0179","authenticated-orcid":false,"given":"Stuart M.","family":"Sprague","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian C.","family":"Covic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Ketteler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco","family":"Botha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjay","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.60"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.907791"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00290109"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.112"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03850609"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00459.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq598"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5414\/CN108119"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.58"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S43486"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.490"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:54:49Z","timestamp":1745427289000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,9,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000447600","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3492608","asserted-by":"subject"}]},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}