{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:13:47Z","timestamp":1792098827994,"version":"4.4.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin &lt;i&gt;(Hamp1)&lt;\/i&gt; is the master regulator of iron and its expression is induced by inflammation. Mice lacking &lt;i&gt;Hamp1&lt;\/i&gt; from birth rapidly accumulate iron and are susceptible to infection by blood-dwelling siderophilic bacteria such as &lt;i&gt;Vibrio vulnificus&lt;\/i&gt;. In order to study the innate immune role of hepcidin against a background of normal iron status, we developed a transgenic mouse model of tamoxifen-sensitive conditional &lt;i&gt;Hamp1&lt;\/i&gt; deletion (termed i&lt;i&gt;Hamp1&lt;\/i&gt;-KO mice). These mice attain adulthood with an iron status indistinguishable from littermate controls. &lt;i&gt;Hamp1&lt;\/i&gt; disruption and the consequent decline of serum hepcidin concentrations occurred within hours of a single tamoxifen dose. We found that the TLR ligands LPS and Pam3CSK4 and heat-killed &lt;i&gt;Brucella abortus&lt;\/i&gt; caused an equivalent induction of inflammation in control and i&lt;i&gt;Hamp1&lt;\/i&gt;-KO mice. Pam3CSK4 and &lt;i&gt;B. abortus&lt;\/i&gt; only caused a drop in serum iron in control mice, while hypoferraemia due to LPS was evident but substantially blunted in i&lt;i&gt;Hamp1&lt;\/i&gt;-KO mice&lt;i&gt;. &lt;\/i&gt;Our results characterise a powerful new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation.<\/jats:p>","DOI":"10.1159\/000447713","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T21:02:00Z","timestamp":1468616520000},"page":"517-528","source":"Crossref","is-referenced-by-count":18,"title":["Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia"],"prefix":"10.1159","volume":"8","author":[{"given":"Andrew E.","family":"Armitage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Jin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe N.","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sant-Rayn","family":"Pasricha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Soilleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Morovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Biggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzi","family":"Gileadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Lakhal-Littleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal","family":"Drakesmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3863"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109062"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101690"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.12.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000713200"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/35001596"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80425-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-550467"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-003376"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061050"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422373112"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nature05541"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351957"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07808.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143354"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2045"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.11.003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-595256"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245977"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1766"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157121"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ng.130"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224577"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3235"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15686"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-505792"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-559484"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/ng.320"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162360699"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2492"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80079-7"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456756"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201485200"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2459"}],"container-title":["Journal of Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:55:43Z","timestamp":1745427343000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000447713","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3490304","asserted-by":"subject"}]},"ISSN":["1662-811X","1662-8128"],"issn-type":[{"value":"1662-811X","type":"print"},{"value":"1662-8128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}