{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:45:51Z","timestamp":1790552751088,"version":"4.1.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;i&gt;Aspergillus fumigatus&lt;\/i&gt; is an opportunistic fungal pathogen that causes severe invasive infections in immunocompromised patients. Innate immunity plays a major role in protection against &lt;i&gt;A. fumigatus.&lt;\/i&gt; The ficolins are a family of soluble pattern recognition receptors that are capable of activating the lectin pathway of complement. Previous in vitro studies reported that ficolins bind to &lt;i&gt;A. fumigatus&lt;\/i&gt;, but their part in host defense against fungal infections in vivo is unknown. In this study, we used ficolin-deficient mice to investigate the role of ficolins during lung infection with &lt;i&gt;A. fumigatus&lt;\/i&gt;. Ficolin knockout mice showed significantly higher fungal loads in the lungs 24 h postinfection compared to wild-type mice. The delayed clearance of &lt;i&gt;A. fumigatus&lt;\/i&gt; in ficolin knockout mice could not be attributed to a compromised recruitment of inflammatory cells. However, it was revealed that ficolin knockout mice exhibited a decreased production of proinflammatory cytokines in the lungs compared to wild-type mice following &lt;i&gt;A. fumigatus &lt;\/i&gt;infection. The impaired clearance and cytokine production in ficolin knockout mice was independent of complement, as shown by equivalent levels of &lt;i&gt;A. fumigatus-&lt;\/i&gt;mediated complement activation in ficolin knockout mice and wild-type mice. In conclusion, this study demonstrates that ficolins are important in initial innate host defense against &lt;i&gt;A. fumigatus&lt;\/i&gt; infections in vivo.<\/jats:p>","DOI":"10.1159\/000447714","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T21:01:31Z","timestamp":1469739691000},"page":"579-588","source":"Crossref","is-referenced-by-count":27,"title":["Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against &lt;b&gt;&lt;i&gt;Aspergillus fumigatus&lt;\/i&gt;&lt;\/b&gt;"],"prefix":"10.1159","volume":"8","author":[{"given":"Ninette","family":"Genster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pr\u00e6stekj\u00e6r 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