{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:10:10Z","timestamp":1745428210672,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We compared 11 patients affected by slow-progression MND with 9 patients presenting typical progression illness. Sera were tested for VGKC-complex Abs by radioimmunoassay. The distribution of VGKC-complex Abs was analyzed with the Mann-Whitney U test. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The statistical analysis showed a significant difference between the mean values in the study and control groups. A case with long-survival MND harboring VGKC-complex Abs and treated with intravenous immunoglobulins is described. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although VGKC-complex Abs are not likely to be pathogenic, these results could reflect the coexistence of an immunological activation in patients with slow disease progression.<\/jats:p>","DOI":"10.1159\/000447715","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T21:21:22Z","timestamp":1475788882000},"page":"59-62","source":"Crossref","is-referenced-by-count":1,"title":["Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease"],"prefix":"10.1159","volume":"17","author":[{"given":"Massimiliano","family":"Godani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zoccarato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Beronio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Zuliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Giometto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Del Sette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Raggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70096-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq213"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.592"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6554-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308695"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305218"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/925101"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24273"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12351"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.143"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.995"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174\/156652411795243450"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02853.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305494"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/17482960903452283"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24460"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24200"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002251"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:55:45Z","timestamp":1745427345000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,7]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,11,1]]},"published-print":{"date-parts":[[2016,11,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000447715","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"type":"print","value":"1660-2854"},{"type":"electronic","value":"1660-2862"}],"subject":[],"published":{"date-parts":[[2016,10,7]]}}}