{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:58:49Z","timestamp":1772456329001,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Objectives:<\/i><\/b> Stratified mucin-producing intraepithelial lesion (SMILE) is an uncommon premalignant lesion of the uterine cervix. A detailed examination of preinvasive SMILE cases including a comparison of the cytologic features with usual-type adenocarcinoma in situ (AIS) and human papillomavirus (HPV) genotyping was performed. <b><i>Study Design:<\/i><\/b> Excisions and preceding Papanicolaou (Pap) tests were retrieved from the files of 2 tertiary care centers. Histologic review estimated the lesional SMILE proportion. Pap tests were reviewed and assessed for architectural, cellular and background features. Cobas\u00ae HPV test was performed. <b><i>Results:<\/i><\/b> 13 cases were identified. Mean\/median patient age was 35\/33 years (range 23-51 years). Concurrent high-grade squamous intraepithelial lesion was found in 10\/13 (77%) and AIS in 8\/13 (62%) cases. In 6 cases, SMILE was dominant (\u226550%) and represented in 5\/6 corresponding Pap tests. Cytology interpretations differed more often in the SMILE-dominant group (p < 0.05). SMILE and AIS had overlapping features. Feathering and prominent nucleoli were absent in SMILE. HPV DNA was detected in all 12 cases tested. HPV 18 was most common (7\/12). Excisions with positive\/suspicious margins were reported in 5\/6 SMILE-dominant versus 3\/7 nondominant cases. <b><i>Conclusion:<\/i><\/b> SMILE is best considered as an AIS variant for cytologic, etiologic and management purposes. Cytologic features overlap with AIS, but are more subtle and easily missed. HPV testing may play a role in facilitating SMILE detection.<\/jats:p>","DOI":"10.1159\/000447940","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T21:01:17Z","timestamp":1469134877000},"page":"225-231","source":"Crossref","is-referenced-by-count":14,"title":["Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: Subtle Features Not to Be Missed"],"prefix":"10.1159","volume":"60","author":[{"given":"Joerg","family":"Schwock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang Mi","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Dub\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Rouzbahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cesari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeina","family":"Ghorab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Geddie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/his.12498"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23381"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000543"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23066"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.139724"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5_5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5_6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.138"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23282"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12217"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-9294.2012.01132.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3385"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20678"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70145-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182887cad"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:57:40Z","timestamp":1745427460000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,8,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000447940","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3494864","asserted-by":"subject"}]},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}