{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:03:31Z","timestamp":1760299411734,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure for the pathological evaluation of the mediastinal nodal (N2) status of lung cancer; however, its feasibility in potentially operable patients with suspicion of minimal N2 disease remains unestablished. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; A prospective multicenter study was conducted to assess the feasibility of EBUS-TBNA in this setting. Patients with clinical stage IIIA-N2 non-small cell lung cancer (NSCLC) and mediastinal nodal enlargement on computed tomography (CT) were eligible; patients were ineligible when CT revealed bulky (&gt; 3 cm in the long-axis diameter) N2 or multiple (\u2265 3) station N2. If EBUS-TBNA revealed negative results, surgical staging procedures were mandatory. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 20 eligible patients, EBUS-TBNA provided pathological confirmation of N2 disease (true-positive) in 12 patients. Among 8 patients with negative results with EBUS-TBNA, 4 patients were pathologically diagnosed as having N2 disease with surgical staging procedures (false-negative), and 4 were finally diagnosed as having non-N2 disease with nodal dissection by thoracotomy (true-negative). As a result, the sensitivity of EBUS-TBNA for N2 evaluation (primary endpoint) was 75.0% (95% confidence interval 47.6-92.7%). No grade 3-5 adverse event were documented. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; EBUS-TBNA is potentially safe and useful in the pathological evaluation of N2 status even in potentially operable NSCLC patients with suspicion of minimal N2 disease on preoperative CT.<\/jats:p>","DOI":"10.1159\/000447989","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T21:01:27Z","timestamp":1471640487000},"page":"629-633","source":"Crossref","is-referenced-by-count":1,"title":["A Multicenter Feasibility Study of EBUS-TBNA for Potentially Operable Non-Small Cell Lung Cancer: The JMTO LC07-02 Study (UMIN000001280)"],"prefix":"10.1159","volume":"39","author":[{"given":"Fumihiro","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Atagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2355"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-011-0529-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31824c945b"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1362"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.07.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181914357"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.5.540"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-1968OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1710"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.08.037"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-013-0224-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2100"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.710"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2535"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447989","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/447989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:58:18Z","timestamp":1745427498000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000447989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000447989","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2016]]}}}