{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:02:30Z","timestamp":1761156150998,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Patients with type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (ATD), and celiac disease (CD) are at increased risk for developing other autoimmune diseases. We evaluated zinc transporter 8 (ZnT8) prevalence in patients with ATD and\/or CD in order to define the usefulness of ZnT8 autoantibodies for prediabetes screening. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eighty-one young patients with ATD and\/or CD were included in the study; 32 subjects with clinical onset of T1DM were enrolled as a control group. GAD65, IA-2, and ZnT8 antibodies were measured. An intravenous glucose tolerance test, C-peptide, glycosylated hemoglobin levels, and genomic analysis of HLA-DQA1* and -DQB1* were also considered in patients positive for autoantibodies. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The ZnT8 prevalence was higher in T1DM patients than in patients with other autoimmune diseases (p &lt; 0.001); positive ZnT8 detection was found in 2 ATD (p = 0.004) and 3 ATD + CD (p = 0.04) patients. Positive ZnT8 was associated with GAD65 (p = 0.01) but not with IA-2 positivity. No correlation between ZnT8 detection and the number of T1DM-susceptible HLA-DQ heterodimers was found. Pathological C-peptide levels and insulin response were found in subjects with islet autoimmunity and genetic susceptibility. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; ZnT8 autoantibodies detection in ATD and\/or CD patients is low, and routine ZnT8 screening is not justified. ZnT8 evaluation may be recommended in subjects with autoimmune diseases as a marker for predicting compromised insulin secretion.<\/jats:p>","DOI":"10.1159\/000448003","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T21:01:30Z","timestamp":1470171690000},"page":"100-105","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease"],"prefix":"10.1159","volume":"86","author":[{"given":"Daniela","family":"Larizza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"De Amici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Albanesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Badulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Calcaterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605223142106"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.03.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.23.99"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800174-5.00014-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0405-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ12-0069"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093326"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12148"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012831"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009001200009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.07.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1487"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0802"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418358"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90140-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90281-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/347151a0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1994.13.505"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705894104"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.9.2330"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01110.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0035"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.741155"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.604658"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.108"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.4.070802.110436"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.11.899"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1995.tb00282.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.005"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.650"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00071.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0131"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2440"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.509120"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003815"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:58:24Z","timestamp":1745427504000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,10,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000448003","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2016]]}}}