{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:13Z","timestamp":1747193353785,"version":"3.40.5"},"reference-count":29,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; The ASC-H cases diagnosed at our institution from 2006 to 2015 were studied retrospectively; of 159,000 Pap smears, there were 959 cases of ASC of undetermined significance (ASC-US) and 148 cases of ASC-H. We have reviewed the clinical records of the ASC-H cases, and data have been analyzed using SPSS 20.0. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Median age was 43.1 years; 49.6% of the patients had previous cervical cytologies, and 55.9% of them were negative. Following ASC-H diagnosis, another smear was obtained in 97.1% of the cases and in 67.6% a biopsy was performed. Biopsy revealed low-grade dysplasia in 18.8% of the cases, high-grade dysplasia in 27.8%, and infiltrating carcinoma in 2.3%. Patients with significant lesions in histology were younger than patients with negative results (p = 0.08). A diagnosis of ASC-H\/squamous intraepithelial lesion in the repeated cytology had a sensitivity of 74.2%, specificity of 39.6%, positive predictive value of 44.8%, and negative predictive value of 70% for the diagnosis of dysplasia. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; ASC-H diagnosis is associated with a high incidence of histological high-grade lesions. A repeat cytology can aid in the selection of high-risk patients, but there may be false-negative results.<\/jats:p>","DOI":"10.1159\/000448022","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T21:02:29Z","timestamp":1470344549000},"page":"217-224","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Relevance of ASC-H Cytologies: Experience in a Single Tertiary Hospital"],"prefix":"10.1159","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-4967","authenticated-orcid":false,"given":"Cristina","family":"D\u00edaz del Arco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa Carmen","family":"Sanabria Montoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Garc\u00eda L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Rodr\u00edguez Escudero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa Jes\u00fas","family":"Fern\u00e1ndez Ace\u00f1ero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1731-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.12.034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32330-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-3015-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1309\/XVB01JQYQNM7MJXU"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22885"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980825)84:4<218::AID-CNCR6>3.0.CO;2-I"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000325475"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23311"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYK60BZRNNAHQ"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21621"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20227"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21387"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.09.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23121"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20334"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21661"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23949"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22170"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802009000500007"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23173"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21664"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21388"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1309\/AGB1-MJ9H-5N43-MEGX"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000337448"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11856"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00758.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2014.1321597"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22982"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448022","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:58:31Z","timestamp":1745427511000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,8,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000448022","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2016]]}}}