{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:36:56Z","timestamp":1789807016893,"version":"4.0.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate the relationship between neuromyelitis optica spectrum disorder (NMOSD) and autoantibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Blood samples of 108 NMOSD patients and 38 controls were collected from January 2012 to August 2014. Immunological parameters, including anti-aquaporin 4, antinuclear, anti-ribonucleoprotein, anti-SM, anti-SSA\/Ro, anti-SSB\/La and anti-ribosomal P-protein autoantibodies were examined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The NMOSD group exhibited a significantly higher percentage of anti-aquaporin 4 antibodies compared with the control group (76.9 vs. 0.0%, p = 0). The positive rates for antinuclear and anti-SSA antibodies in the NMOSD group were also higher than in the control group (35.2 vs. 11.8%, p = 0.001; 13.0 vs. 0.0%, p = 0.044). In total, 36.1% of the patients in the NMOSD group were seropositive for autoantibodies but only 8.3% were diagnosed with definite systemic autoimmune disorders. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; NMOSD is closely associated with elevated autoantibodies, particularly antinuclear and anti-SSA\/Ro antibodies. NMOSD rarely coexists with organ-specific autoimmune diseases.<\/jats:p>","DOI":"10.1159\/000448286","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T21:05:04Z","timestamp":1473282304000},"page":"151-156","source":"Crossref","is-referenced-by-count":14,"title":["Multiple Autoantibodies and Neuromyelitis Optica Spectrum Disorders"],"prefix":"10.1159","volume":"23","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Xiaobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yaqing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lisheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhengqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000110"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000204"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12271"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000134"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1220-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000104"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511403958"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431728"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1502-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.03.038"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.964"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065385"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6677-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2298\/VSP1311056S"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431077"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000062"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000163"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000060"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:01:50Z","timestamp":1745427710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000448286","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}