{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:32:45Z","timestamp":1777267965090,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2016]]},"abstract":"The t(12;17)(p13;q11\u223c21) translocation is a very rare but recurrent cytogenetic aberration observed predominantly in early pre-B acute lymphoblastic leukemia (ALL) with CD19+CD10-CD33+ phenotype. This translocation was shown to form a fusion gene between <i>TAF15<\/i> at 17q12 and <i>ZNF384<\/i> at 12p13. On the other hand, der(1;18)(q10;q10) has been detected as a rare unbalanced whole-arm translocation leading to trisomy 1q in myeloid malignancies. We describe here the first case of mixed phenotype acute leukemia (MPAL) with a t(12;17)(p13;q21)\/<i>TAF15-ZNF384<\/i>, which also had der(1;18)(q10;q10) as an additional abnormality. A 74-year-old woman was diagnosed with MPAL, B\/myeloid, because bone marrow blasts were positive for myeloperoxidase, CD19, and CD22. Chromosome analysis showed 46,XX, +1,der(1;18)(q10;q10),t(2;16)(q13;q13),t(12;17)(p13;q21). Expression of the <i>TAF15-ZNF384<\/i> fusion transcript was confirmed: <i>TAF15<\/i> exon 6 was fused in-frame to <i>ZNF384<\/i> exon 3. This type of fusion gene has been reported in 1 acute myeloid leukemia case and 3 ALL cases. Thus, at present, it is difficult to find a specific association between the structure of the <i>TAF15-ZNF384<\/i> fusion gene and the leukemia phenotype. The <i>TAF15-ZNF384<\/i> fusion may occur in early common progenitor cells that could differentiate into both the myeloid and lymphoid lineages. Furthermore, der(1;18)(q10;q10) might play some role in the appearance of an additional myeloid phenotype.<\/jats:p>","DOI":"10.1159\/000448447","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T21:01:30Z","timestamp":1473368490000},"page":"165-170","source":"Crossref","is-referenced-by-count":12,"title":["Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)\/<b><i>TAF15-ZNF384<\/i><\/b> and Other Chromosome Abnormalities"],"prefix":"10.1159","volume":"149","author":[{"given":"Katsuya","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Yakushijin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoe","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nakamachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitake","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Minami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.10.013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.02.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.753450"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403842"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/ell015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90317-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1482-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.01.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2005.07.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00391-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.202"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448447","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:03:43Z","timestamp":1745427823000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,11,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000448447","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}