{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:33:36Z","timestamp":1790062416813,"version":"4.0.1"},"reference-count":17,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":3455,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue, accounting for approximately 5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most SO cases are benign with only 5-10% being malignant, and malignant SO causing thyrotoxicosis is very uncommon. Case: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years previously. The thyroid gland was palpable with a micronodular texture, and the patient was euthyroid under carbimazole. She presented with abdominal pain and progressive enlargement of the abdomen over a 2-month period. An abdominal ultrasonography revealed a pelvic mass and a large fluid collection. Additional imaging confirmed the presence of a complex right ovarian mass measuring 13 cm. The patient underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy, omentectomy and appendectomy. The histological examination revealed the presence of \u2018follicular thyroid-type carcinoma arising in an SO of the right ovary, with metastatic infiltration in the tissue fragments from the pouch of Douglas'. Antithyroid treatment was discontinued 1 month after surgery in light of the pathology result. During the 4-year follow-up, the patient remained euthyroid. Conclusion: There has been controversy about the management of malignant SO, which is a rare entity. Malignant SO causing thyrotoxicosis is even more uncommon. As clinical signs are nonspecific, other causes of thyrotoxicosis must be considered for a differential diagnosis. Our case is one of the very few cases ever reported.<\/jats:p>","DOI":"10.1159\/000448474","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T17:04:17Z","timestamp":1473267857000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":16,"title":["An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis"],"prefix":"10.1530","volume":"5","author":[{"given":"Elli","family":"Anagnostou","sequence":"first","affiliation":[{"name":"1Departments of Endocrinology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Polymeris","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Morphopoulos","sequence":"additional","affiliation":[{"name":"2Departments of Pathology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Travlos","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Sarantopoulou","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irini","family":"Papaspyrou","sequence":"additional","affiliation":[{"name":"2Departments of Pathology, Alexandra General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"2026070712474522600_ref1","unstructured":"Kondi-Pafiti A, Mavrigiannaki P, Grigoriadis C, Kontogianni-Katsarou K, Mellou A, Kleanthis CK, Liapis A: Monodermal teratomas (struma ovarii). Clinicopathological characteristics of 11 cases and literature review. Eur J Gynaecol Oncol 2011;32:657-659.22335029"},{"key":"2026070712474522600_ref2","doi-asserted-by":"crossref","unstructured":"Yoo SC, Chang KH, Lyu MO, Chang SJ, Ryu HS, Kim HS: Clinical characteristics of struma ovarii. J Gynecol Oncol 2008;19:135-138.10.3802\/jgo.2008.19.2.13519471561","DOI":"10.3802\/jgo.2008.19.2.135"},{"key":"2026070712474522600_ref3","doi-asserted-by":"crossref","unstructured":"Rosenblum NG, LiVolsi VA, Edmonds PR, Mikuta JJ: Malignant struma ovarii. Gynecol Oncol 1989;32:224-227.10.1016\/S0090-8258(89)80037-X2910784","DOI":"10.1016\/S0090-8258(89)80037-X"},{"key":"2026070712474522600_ref4","doi-asserted-by":"crossref","unstructured":"Volpi E, Ferrero A, Nasi PG, Sismondi P: Malignant struma ovarii: a case report of laparoscopic management. Gynecol Oncol 2003;90:191-194.10.1016\/S0090-8258(03)00142-212821363","DOI":"10.1016\/S0090-8258(03)00142-2"},{"key":"2026070712474522600_ref5","doi-asserted-by":"crossref","unstructured":"Dardik RB, Dardik M, Westra W, Montz FJ: Malignant struma ovarii: two case reports and a review of the literature. Gynecol Oncol 1999;73:447-451.10.1006\/gyno.1999.535510366477","DOI":"10.1006\/gyno.1999.5355"},{"key":"2026070712474522600_ref6","doi-asserted-by":"crossref","unstructured":"Young RH: New and unusual aspects of ovarian germ cell tumors. Am J Surg Pathol 1993;17:1210-1224.10.1097\/00000478-199312000-000027694512","DOI":"10.1097\/00000478-199312000-00002"},{"key":"2026070712474522600_ref7","doi-asserted-by":"crossref","unstructured":"Kung AW, Ma JT, Wang C, Young RT: Hyperthyroidism during pregnancy due to coexistence of struma ovarii and Graves' disease. Postgrad Med J 1990;66:132-133.10.1136\/pgmj.66.772.1322349185","DOI":"10.1136\/pgmj.66.772.132"},{"key":"2026070712474522600_ref8","doi-asserted-by":"crossref","unstructured":"Teale E, Gouldesbrough DR, Peacey SR: Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. Thyroid 2006;16:791-793.10.1089\/thy.2006.16.79116910883","DOI":"10.1089\/thy.2006.16.791"},{"key":"2026070712474522600_ref9","doi-asserted-by":"crossref","unstructured":"Matsuda K, Maehama T, Kanazawa K: Malignant struma ovarii with thyrotoxicosis. Gynecol Oncol 2001;82:575-577.10.1006\/gyno.2001.631511520159","DOI":"10.1006\/gyno.2001.6315"},{"key":"2026070712474522600_ref10","doi-asserted-by":"crossref","unstructured":"Kim D, Cho HC, Park JW, Lee WA, Kim YM, Chung PS, Park SG, Ahn WS, Han SJ, Park CH: Struma ovarii and peritoneal strumosis with thyrotoxicosis. Thyroid 2009;19:305-308.10.1089\/thy.2008.030719265502","DOI":"10.1089\/thy.2008.0307"},{"key":"2026070712474522600_ref11","doi-asserted-by":"crossref","unstructured":"Salman WD, Singh M, Twaij Z: A case of papillary thyroid carcinoma in struma ovarii and review of the literature. Patholog Res Int 2010;2:352476.10.4061\/2010\/35247621151690","DOI":"10.4061\/2010\/352476"},{"key":"2026070712474522600_ref12","doi-asserted-by":"crossref","unstructured":"Selvaggi F, Risio D, Waku M, Simo D, Angelucci D, D'Aulerio A, Cotellese R, Innocenti P: Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report. World J Surg Oncol 2012;21:93.10.1186\/1477-7819-10-9322613573","DOI":"10.1186\/1477-7819-10-93"},{"key":"2026070712474522600_ref13","doi-asserted-by":"crossref","unstructured":"Roth LM, Talerman A: The enigma of struma ovarii. Pathology 2007;39:139-146.10.1080\/0031302060112397917365830","DOI":"10.1080\/00313020601123979"},{"key":"2026070712474522600_ref14","doi-asserted-by":"crossref","unstructured":"Roth LM, Karseladze A: Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol 2008;27:213-222.18317221","DOI":"10.1097\/PGP.0b013e318158e958"},{"key":"2026070712474522600_ref15","doi-asserted-by":"crossref","unstructured":"DeSimone CP, Lele SM, Modesitt SC: Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. Gynecol Oncol 2003;89:543-548.10.1016\/S0090-8258(03)00141-012798728","DOI":"10.1016\/S0090-8258(03)00141-0"},{"key":"2026070712474522600_ref16","doi-asserted-by":"crossref","unstructured":"Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E: A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 2007;115:397-400.10.1055\/s-2007-97385317701887","DOI":"10.1055\/s-2007-973853"},{"key":"2026070712474522600_ref17","doi-asserted-by":"crossref","unstructured":"Emge LA: Functional and growth characteristics of struma ovarii. J Obstet Gynecol 1940;40:738-749.10.1016\/S0002-9378(15)30800-0","DOI":"10.1016\/S0002-9378(15)30800-0"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/5\/3\/207\/29680\/etj448474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/5\/3\/207\/29680\/etj448474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:10:39Z","timestamp":1783444239000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/5\/3\/207\/4012\/An-Unusual-Case-of-Malignant-Struma-Ovarii-Causing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000448474","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}