{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T21:47:58Z","timestamp":1783288078186,"version":"3.54.6"},"reference-count":14,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Approximately 10% of pancreatic neuroendocrine tumors (NET) are associated with familial syndromes, with the most common type being multiple endocrine neoplasia type 1 (MEN-1). However, the available evidence on how to treat NET comes from studies in sporadic NET. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; Here we report the case of a 51-year-old male patient with a metastatic MEN-1-associated pancreatic NET and hypercalcemia related to primary hyperparathyroidism and tumor-secreted parathyroid-related protein. The patient was treated with everolimus, and showed complete resolution of hypercalcemia and tumor control for 3 years when he presented with pulmonary cryptococcosis and disease progression. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This case report describes the activity of everolimus in a patient with MEN-1-associated pancreatic NET, its efficacy in treating malignant hypercalcemia associated with NET and the risk of opportunistic infections with prolonged use of this agent.<\/jats:p>","DOI":"10.1159\/000448699","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T21:01:21Z","timestamp":1473714081000},"page":"643-645","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Long-Term Safety of Everolimus in Pancreatic Neuroendocrine Tumor Associated with Multiple Endocrine Neoplasia Type I: Case Report"],"prefix":"10.1159","volume":"39","author":[{"given":"Manuel C.D.F.","family":"Maia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delmar","family":"Muniz Louren\u00e7o Jr.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Riechelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-29"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2227-684X.2014.12.01"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200609"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009290"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000431385"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003825"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3221"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1315"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0806740"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61742-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000207"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0150-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.278"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25219"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448699","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:05:23Z","timestamp":1745427923000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000448699","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}