{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:44:42Z","timestamp":1780983882739,"version":"3.54.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Although mortality has decreased for fetuses with lower urinary tract obstruction treated with vesicoamniotic shunt (VAS) placement, survivors remain at risk for long-term renal impairment. We tested the association of fetal serum \u03b2&lt;sub&gt;2&lt;\/sub&gt;-microglobulin (fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M) with postnatal renal function in these patients, hypothesizing that fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M may predict such renal impairment. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M was obtained in patients undergoing VAS placement. The primary outcome was renal function at 3-12 months of life, as assessed by a pediatric nephrologist using medical records. Patients were divided into two groups: (1) \u2018stable renal function' - probable stable long-term renal function and reasonable growth - and (2) \u2018loss of renal function' - early loss of renal function and failure to thrive. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Nineteen patients with preoperative fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M received a VAS. Of the 14 survivors, those with fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M \u22645.6 mg\/l tended to have stable renal function compared to those with fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M &gt;5.6 mg\/l [5\/6 (83.3%) vs. 2\/8 (25.0%), OR = 15.00, 95% CI 0.70-709.89; p = 0.1026]. Eight of 9 patients followed for &gt;12 months of age had outcomes consistent with the initial renal assessments. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; Patients with initial fs\u03b2&lt;sub&gt;2&lt;\/sub&gt;M &gt;5.6 mg\/l and treated with VAS tended to have poor renal outcomes.<\/jats:p>","DOI":"10.1159\/000448952","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T21:05:04Z","timestamp":1473282304000},"page":"17-27","source":"Crossref","is-referenced-by-count":7,"title":["Fetal Serum \u03b2&lt;sub&gt;2&lt;\/sub&gt;-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt"],"prefix":"10.1159","volume":"42","author":[{"given":"Andrew H.","family":"Chon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo H.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin V.","family":"Lemley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Korst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramen H.","family":"Chmait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,9,8]]},"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/448952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:56Z","timestamp":1745428076000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000448952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,26]]},"published-print":{"date-parts":[[2017,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000448952","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}