{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:51:47Z","timestamp":1789897907687,"version":"4.0.1"},"reference-count":45,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Voltage-gated potassium (Kv) channels formed by Kv7 (KCNQ) \u03b1-subunits are recognized as crucial for vascular smooth muscle function, in addition to their established roles in the heart (Kv7.1) and the brain (Kv7.2-5). In vivo, Kv7 \u03b1-subunits are often regulated by KCNE subfamily ancillary (\u03b2) subunits. We investigated the effects of targeted germline &lt;i&gt;Kcne4&lt;\/i&gt; deletion on mesenteric artery reactivity in adult male and female mice. &lt;i&gt;Kcne4&lt;\/i&gt; deletion increased mesenteric artery contractility in response to \u03b1-adrenoceptor agonist methoxamine, and decreased responses to Kv7.2-7.5 channel activator ML213, in male but not female mice. In contrast, &lt;i&gt;Kcne4&lt;\/i&gt; deletion markedly decreased vasorelaxation in response to isoprenaline in both male and female mice. &lt;i&gt;Kcne4&lt;\/i&gt; expression was 2-fold lower in the female versus the male mouse mesenteric artery, and &lt;i&gt;Kcne4&lt;\/i&gt; deletion elicited only moderate changes of other &lt;i&gt;Kcne&lt;\/i&gt; transcripts, with no striking sex-specific differences. However, Kv7.4 protein expression in females was twice that in males, and was reduced in both sexes by &lt;i&gt;Kcne4&lt;\/i&gt; deletion. Our findings confirm a crucial role for KCNE4 in regulation of Kv7 channel activity to modulate vascular tone, and provide the first known molecular mechanism for sex-specificity of this modulation that has important implications for vascular reactivity and may underlie sex-specific susceptibility to cardiovascular diseases.<\/jats:p>","DOI":"10.1159\/000449060","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T21:22:14Z","timestamp":1475788934000},"page":"138-148","source":"Crossref","is-referenced-by-count":38,"title":["Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity"],"prefix":"10.1159","volume":"53","author":[{"given":"Geoffrey W.","family":"Abbott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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