{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:26:23Z","timestamp":1790083583706,"version":"4.0.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg\/dl (baseline) to 733 mg\/dl (after chemotherapy) (p &lt; 0.001). Although CD20+ and CD4+ cell counts decreased (p &lt; 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for &gt;2 years, although sIgG levels were restored more quickly than CD4+ cell counts.<\/jats:p>","DOI":"10.1159\/000449251","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T21:01:58Z","timestamp":1475096518000},"page":"302-310","source":"Crossref","is-referenced-by-count":21,"title":["Influence of R-CHOP Therapy on Immune System Restoration in Patients with B-Cell Lymphoma"],"prefix":"10.1159","volume":"91","author":[{"given":"Kaori","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Inaguma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinao","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tsuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Tomono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kakumae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Emi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.6929"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1674"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2031"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62175-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi320a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.164"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3411"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21264"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hon.947"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl141"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.11.011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012500524758"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0758-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker417"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-178"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2135-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.921298"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1110748"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:10:36Z","timestamp":1745428236000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000449251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000449251","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}