{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:11:06Z","timestamp":1761581466978,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Evaluating the predictive factors that enable identifying men in which a sole MRI\/ultrasound (MRI\/US) fusion-guided targeted biopsy (TB) detects the maximal prostate cancer (PCa) risk group. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Retrospective analysis of 251 consecutive patients who received a sensor-based, real-time MRI\/US TB in combination with a 10-core systematic biopsy (SB) between August 2013 and July 2015. Univariate and multivariate binary regression analyses were performed to evaluate the predictors for equal\/superior detection of the PCa risk group by TB compared to SB. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; TB detected PCa in 63% (157\/251); SB detected PCa in 70% (176\/251); a combination of TB and SB detected PCa in 77% (193\/251) of cancer patients. Fifty percent (291\/584) of TB cores and 22% (539\/2,486) of SB cores showed PCa. Predictors for equal\/superior performance of a sole TB were lesion size (maximal diameter; OR 1.050, 95% CI 1.002-1.101, p = 0.043), suspicious digital rectal examination (DRE; OR 2.448, 95% CI 1.062-5.645, p = 0.036) and free\/total prostate-specific antigen (PSA) ratio (f\/t PSA ratio) \u22640.15 (OR 0.916, 95% CI 0.867-0.967, p = 0.002) on univariate regression analysis and f\/t PSA ratio \u22640.15 (OR 0.916, 95% CI 0.867-0.967, p = 0.002) on multivariate regression analysis. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The maximal axial diameter of the Prostate Imaging Reporting and Data System-lesion and f\/t PSA ratio and a suspicious DRE are possible selection criteria for men eligible for a sole MRI\/US fusion-guided targeted prostate biopsy.<\/jats:p>","DOI":"10.1159\/000449258","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T21:01:21Z","timestamp":1473714081000},"page":"15-21","source":"Crossref","is-referenced-by-count":5,"title":["Predictive Parameters Identifying Men Eligible for a Sole MRI\/Ultrasound Fusion-Guided Targeted Biopsy without an Additional Systematic Biopsy"],"prefix":"10.1159","volume":"98","author":[{"given":"Karsten","family":"G\u00fcnzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Maxeiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Buckendahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Asbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Kempkensteffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Cash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,9,13]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:10:38Z","timestamp":1745428238000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000449258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,13]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,25]]},"published-print":{"date-parts":[[2017,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000449258","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.3823953","asserted-by":"subject"}]},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2016,9,13]]}}}