{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:43:11Z","timestamp":1790815391262,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Hydrogen sulfide (H&lt;sub&gt;2&lt;\/sub&gt;S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-&amp;#x03B3;-lyase (CSE), cystathionine-\u03b2-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase. The H&lt;sub&gt;2&lt;\/sub&gt;S-forming enzymes, particularly CSE, are overexpressed under the pathological conditions such as inflammation, neuronal or neuroendocrine differentiation and cancer development. Given that Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 T-type Ca&lt;sup&gt;2+&lt;\/sup&gt; channels mediate some of the biological activity of H&lt;sub&gt;2&lt;\/sub&gt;S, we focus on the role of the H&lt;sub&gt;2&lt;\/sub&gt;S\/Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 pathway in regulating the neuronal and neuroendocrine function. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; In the neuronal system, H&lt;sub&gt;2&lt;\/sub&gt;S regulates the activity of various ion channels including Ca&lt;sub&gt;v&lt;\/sub&gt;3.2. Exogenous and endogenous H&lt;sub&gt;2&lt;\/sub&gt;S enhances the Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 channel activity, promoting somatic and visceral pain signaling. The H&lt;sub&gt;2&lt;\/sub&gt;S\/Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 pathway also facilitates neuritogenesis or neuronal differentiation. Interestingly, endogenous H&lt;sub&gt;2&lt;\/sub&gt;S formed by CSE regulates secretory function by enhancing Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 channel activity in neuroendocrine-differentiated prostate cancer cells or carotid glomus cells. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; The H&lt;sub&gt;2&lt;\/sub&gt;S\/Ca&lt;sub&gt;v&lt;\/sub&gt;3.2 pathway may serve as therapeutic targets for treatment of intractable pain, neuronal injury, androgen-independent prostate cancer, cardiovascular diseases, etc.<\/jats:p>","DOI":"10.1159\/000449449","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T22:01:42Z","timestamp":1481234502000},"page":"196-203","source":"Crossref","is-referenced-by-count":30,"title":["Hydrogen Sulfide and T-Type Ca&lt;sup&gt;2+&lt;\/sup&gt; Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion"],"prefix":"10.1159","volume":"99","author":[{"given":"Kazuki","family":"Fukami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsufumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,12,9]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/449449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:12:51Z","timestamp":1745428371000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000449449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,3,2]]},"published-print":{"date-parts":[[2017,3,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000449449","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}