{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:22:45Z","timestamp":1787066565630,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking. <b><i>Objective:<\/i><\/b> We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation. <b><i>Methods:<\/i><\/b> 17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (<i>n<\/i> = 6) and without (<i>n<\/i> = 11) depression and controls were evaluated using FreeSurfer software. <b><i>Results:<\/i><\/b> Cortical thickness was increased in the precuneus bilaterally in PD patients with depression compared to the other groups (number of vertices >100; <i>p<\/i> < 0.001, uncorrected) with a direct correlation with the Beck Depression Inventory score (<i>p<\/i> < 0.001, uncorrected). <b><i>Conclusion:<\/i><\/b> Precuneal cortical thickening is evident in PD patients with mild-moderate depression even in the early stages of the disease. This finding may reflect the early involvement of this region in the development of PD-related depression.<\/jats:p>","DOI":"10.1159\/000450614","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T17:01:37Z","timestamp":1480006897000},"page":"97-102","source":"Crossref","is-referenced-by-count":21,"title":["Precuneal Thickness and Depression in Parkinson 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