{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:48:16Z","timestamp":1787694496091,"version":"build-2784847793"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; A head to head comparison study on renal function and ductal response between indomethacin and ibuprofen has rarely been conducted in extremely low birth weight (ELBW) infants. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim was to compare renal function and ductal response between indomethacin and ibuprofen in ELBW infants. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We performed a double-blind randomized control trial to compare renal function and ductal response between indomethacin (0.2, 0.1, and 0.1 mg\/kg i.v. every 24 h for 3 doses) and ibuprofen lysine (10, 5, and 5 mg\/kg i.v. every 24 h for 3 doses) in ELBW infants with significant hemodynamic patent ductus arteriosus (cardiovascular dysfunction score &gt;3 and LA\/AO ratio \u22651.3). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 144 infants were enrolled: 73 received indomethacin and 71 received ibuprofen lysine. Significant decreases in urine output were seen in 30 infants (41%) in the indomethacin group and 15 (21%) in the ibuprofen group (p = 0.02). The indomethacin group was associated with a significantly higher chance of persistent ductal response than the ibuprofen group (66 vs. 49%, p = 0.046), but with a lower glomerular filtration rate on day 1, higher serum creatinine on days 1, 2, and 7, and lower urinary prostaglandin on days 2-7. Both groups were comparable in mortality and in bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy of prematurity morbidity. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; With the current dosage, ibuprofen had fewer renal side effects but was associated with a lower rate of persistent ductal closure in ELBW infants. The precise role of prostaglandin on renal tubular function in ELBW infants remains to be further investigated.<\/jats:p>","DOI":"10.1159\/000450822","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T17:04:08Z","timestamp":1479143048000},"page":"195-202","source":"Crossref","is-referenced-by-count":17,"title":["Randomized Trial to Compare Renal Function and Ductal Response between Indomethacin and Ibuprofen Treatment in Extremely Low Birth Weight Infants"],"prefix":"10.1159","volume":"111","author":[{"given":"Yuh Jyh","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-8957","authenticated-orcid":false,"given":"Chung Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender K.","family":"Rehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Florens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou Yien","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Luen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung T.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu Kuei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu F.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.168682"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1596-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198109000-00009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/0471445428.ch4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003481.pub6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80022-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17477-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80560-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.50.1.27"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000092870"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00453.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03118.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.4.e49"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858640"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90396-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7563"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11693"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000087582"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.320"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2007.04.006"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450822","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:16:09Z","timestamp":1745414169000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000450822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000450822","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}