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Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Bcl-2, the first gene shown to be involved in apoptosis, is a potent regulator of cell survival and known to have protective effects against a variety of age-related diseases. However, the possible relationship between hearing and Bcl-2 expression in the cochlea or auditory cortex of C57BL\/6 mice, a mouse model of age-related hearing loss, is still unknown. Using RT-PCR, immunohistochemistry, and Western blot analysis, our results show that Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging. The expression pattern of Bcl-2 in the peripheral and central auditory systems suggests that Bcl-2 may play an important role in auditory function serving as a protective molecule against age-related hearing loss.<\/jats:p>","DOI":"10.1159\/000450937","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T22:03:45Z","timestamp":1481148225000},"page":"326-332","source":"Crossref","is-referenced-by-count":10,"title":["Differential Expression of Bcl-2 in the Cochlea and Auditory Cortex of a Mouse Model of Age-Related Hearing Loss"],"prefix":"10.1159","volume":"21","author":[{"given":"Qiuhong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkang","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0356-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0383-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.01.037"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199810)252:2<165::AID-AR2>3.0.CO;2-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0411"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401230"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67423-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/348334a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02092.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00249.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/40.12.1453000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.04.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S93732"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0363"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9601-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4277-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.12.006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21533"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/10400435.2010.483646"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-107"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00003-9"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450937","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/450937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:16:58Z","timestamp":1745428618000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000450937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,1,25]]},"published-print":{"date-parts":[[2017,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000450937","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}